@article{oai:niigata-u.repo.nii.ac.jp:00019180,
 author = {原, 勝利 and 石橋, 隆治 and 濱口, 政巳 and 今井, 昭一},
 issue = {8},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Aug},
 note = {We have examined the effects of lacidipine, a new dihydropyridine calcium antagonist, on cardiohemodynamics in comparison with those of nifedipine. Experiments were performed in open- and close-chest dogs anesthetized with morphine-α-chloralose-urethane and nitrous oxide. Lacidipine and nifedipine were administered intravenously at 1～30μg/kg. In open-chest dogs, both lacidipine and nifedipine produced dose-dependent decreases in diastolic and mean blood pressures (DBP and MBP) and increases in heart rate (HR) and left ventricular max dP/dt (LV max dP/dt). The decrease in MBP produced by nifedipine was transient; the MBP recovered to a level almost equal to the predrug level in a few minutes. In contrast, the effects of lacidipine were more prolonged except at low dose levels. On the basis of half-life assessed at a dose causing a decrement of MBP of a similar magnitude the hypotensive effect of lacidipine was >9 times longer-lasting than that of nifedipine. Both nifedipine and lacidipine decreased systolic blood pressure (SBP), left ventricular pressure (LVP) and left ventricular end-diastolic pressure (LVEDP) and increased cardiac output (CO). Lacidipine and nifedipine decreased total peripheral resistance (TPR) dose-dependently. The decreases were 20～50% for lacidipine and 15～40 % for nifedipine. Coronary blood flow (Cor-F) was increased to 50～175 % of the control after lecidipine and coronary vascular resistance (Cor-R) was decreased to 25～75%, while the changes were 40～240% and 35～70% after nifedipine. Decreases and increases were dose-dependent with both drugs. The increases in Cor-F exceeded those expected from the increases in MVO_2 observed simultaneously. In close-chest dogs, both nifedipine and lacidipine increased carotid and femoral blood flow (Car-F and Fern-F) and dose-dependently decreased carotid and femoral vascular resistance (Car-R and Fem-R). Coincident with the fall in BP renal blood flow (Ren-F) was decreased. Renal vascular resistance (Ren-R) was slightly decreased at all doses except for the maximum dose, at which it increased. The changes observed in blood flow in these vascular beds were less than 50% at the maximum and those in vascular resistance were less than 35%. Changes in MBP and HR were similar to those observed in open-chest dogs. Duration of action of lacidipine was longer than that of nifedipine. Like nifedipine the action of lacidipine was selective towards coronary artery.},
 pages = {593--608},
 title = {新規カルシウム拮抗薬 Lacidipineの心血行動態に対する作用},
 volume = {108},
 year = {1994}
}