WEKO3
アイテム
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Experiments were performed in open- and close-chest dogs anesthetized with morphine-α-chloralose-urethane and nitrous oxide. Lacidipine and nifedipine were administered intravenously at 1~30μg/kg. In open-chest dogs, both lacidipine and nifedipine produced dose-dependent decreases in diastolic and mean blood pressures (DBP and MBP) and increases in heart rate (HR) and left ventricular max dP/dt (LV max dP/dt). The decrease in MBP produced by nifedipine was transient; the MBP recovered to a level almost equal to the predrug level in a few minutes. In contrast, the effects of lacidipine were more prolonged except at low dose levels. On the basis of half-life assessed at a dose causing a decrement of MBP of a similar magnitude the hypotensive effect of lacidipine was \u003e9 times longer-lasting than that of nifedipine. Both nifedipine and lacidipine decreased systolic blood pressure (SBP), left ventricular pressure (LVP) and left ventricular end-diastolic pressure (LVEDP) and increased cardiac output (CO). Lacidipine and nifedipine decreased total peripheral resistance (TPR) dose-dependently. The decreases were 20~50% for lacidipine and 15~40 % for nifedipine. Coronary blood flow (Cor-F) was increased to 50~175 % of the control after lecidipine and coronary vascular resistance (Cor-R) was decreased to 25~75%, while the changes were 40~240% and 35~70% after nifedipine. Decreases and increases were dose-dependent with both drugs. The increases in Cor-F exceeded those expected from the increases in MVO_2 observed simultaneously. In close-chest dogs, both nifedipine and lacidipine increased carotid and femoral blood flow (Car-F and Fern-F) and dose-dependently decreased carotid and femoral vascular resistance (Car-R and Fem-R). Coincident with the fall in BP renal blood flow (Ren-F) was decreased. 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新規カルシウム拮抗薬 Lacidipineの心血行動態に対する作用
http://hdl.handle.net/10191/38416
http://hdl.handle.net/10191/38416bca210f7-a66d-429e-b4e5-b928f4d97384
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-02-18 | |||||
タイトル | ||||||
タイトル | 新規カルシウム拮抗薬 Lacidipineの心血行動態に対する作用 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 新規カルシウム拮抗薬 Lacidipineの心血行動態に対する作用 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lacidipine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nifedipine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | calcium antagonist | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dog | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | カルシウム拮抗薬 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 心血行動態 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 心筋酸素消費量 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Cardiohemodynamic Effects of Lacidipine, a Novel Calcium Antagonist | |||||
著者 |
原, 勝利
× 原, 勝利× 石橋, 隆治× 濱口, 政巳× 今井, 昭一 |
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著者別名 | ||||||
識別子 | 119448 | |||||
識別子Scheme | WEKO | |||||
姓名 | Hara, Katsutoshi | |||||
著者別名 | ||||||
識別子 | 119449 | |||||
識別子Scheme | WEKO | |||||
姓名 | Ishibashi, Takaharu | |||||
著者別名 | ||||||
識別子 | 119450 | |||||
識別子Scheme | WEKO | |||||
姓名 | Hamaguchi, Masami | |||||
著者別名 | ||||||
識別子 | 119451 | |||||
識別子Scheme | WEKO | |||||
姓名 | Imai, Shoichi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We have examined the effects of lacidipine, a new dihydropyridine calcium antagonist, on cardiohemodynamics in comparison with those of nifedipine. Experiments were performed in open- and close-chest dogs anesthetized with morphine-α-chloralose-urethane and nitrous oxide. Lacidipine and nifedipine were administered intravenously at 1~30μg/kg. In open-chest dogs, both lacidipine and nifedipine produced dose-dependent decreases in diastolic and mean blood pressures (DBP and MBP) and increases in heart rate (HR) and left ventricular max dP/dt (LV max dP/dt). The decrease in MBP produced by nifedipine was transient; the MBP recovered to a level almost equal to the predrug level in a few minutes. In contrast, the effects of lacidipine were more prolonged except at low dose levels. On the basis of half-life assessed at a dose causing a decrement of MBP of a similar magnitude the hypotensive effect of lacidipine was >9 times longer-lasting than that of nifedipine. Both nifedipine and lacidipine decreased systolic blood pressure (SBP), left ventricular pressure (LVP) and left ventricular end-diastolic pressure (LVEDP) and increased cardiac output (CO). Lacidipine and nifedipine decreased total peripheral resistance (TPR) dose-dependently. The decreases were 20~50% for lacidipine and 15~40 % for nifedipine. Coronary blood flow (Cor-F) was increased to 50~175 % of the control after lecidipine and coronary vascular resistance (Cor-R) was decreased to 25~75%, while the changes were 40~240% and 35~70% after nifedipine. Decreases and increases were dose-dependent with both drugs. The increases in Cor-F exceeded those expected from the increases in MVO_2 observed simultaneously. In close-chest dogs, both nifedipine and lacidipine increased carotid and femoral blood flow (Car-F and Fern-F) and dose-dependently decreased carotid and femoral vascular resistance (Car-R and Fem-R). Coincident with the fall in BP renal blood flow (Ren-F) was decreased. Renal vascular resistance (Ren-R) was slightly decreased at all doses except for the maximum dose, at which it increased. The changes observed in blood flow in these vascular beds were less than 50% at the maximum and those in vascular resistance were less than 35%. Changes in MBP and HR were similar to those observed in open-chest dogs. Duration of action of lacidipine was longer than that of nifedipine. Like nifedipine the action of lacidipine was selective towards coronary artery. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 108, 号 8, p. 593-608, 発行日 1994-08 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |