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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第108巻第8号

新規カルシウム拮抗薬 Lacidipineの心血行動態に対する作用

http://hdl.handle.net/10191/38416
http://hdl.handle.net/10191/38416
bca210f7-a66d-429e-b4e5-b928f4d97384
名前 / ファイル ライセンス アクション
108(8)_593-608.pdf 108(8)_593-608.pdf (2.4 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-02-18
タイトル
タイトル 新規カルシウム拮抗薬 Lacidipineの心血行動態に対する作用
タイトル
言語 en
タイトル 新規カルシウム拮抗薬 Lacidipineの心血行動態に対する作用
言語
言語 jpn
キーワード
主題Scheme Other
主題 lacidipine
キーワード
主題Scheme Other
主題 nifedipine
キーワード
主題Scheme Other
主題 calcium antagonist
キーワード
主題Scheme Other
主題 dog
キーワード
主題Scheme Other
主題 カルシウム拮抗薬
キーワード
主題Scheme Other
主題 心血行動態
キーワード
主題Scheme Other
主題 心筋酸素消費量
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Cardiohemodynamic Effects of Lacidipine, a Novel Calcium Antagonist
著者 原, 勝利

× 原, 勝利

WEKO 119444

原, 勝利

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石橋, 隆治

× 石橋, 隆治

WEKO 119445

石橋, 隆治

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濱口, 政巳

× 濱口, 政巳

WEKO 119446

濱口, 政巳

Search repository
今井, 昭一

× 今井, 昭一

WEKO 119447

今井, 昭一

Search repository
著者別名
識別子 119448
識別子Scheme WEKO
姓名 Hara, Katsutoshi
著者別名
識別子 119449
識別子Scheme WEKO
姓名 Ishibashi, Takaharu
著者別名
識別子 119450
識別子Scheme WEKO
姓名 Hamaguchi, Masami
著者別名
識別子 119451
識別子Scheme WEKO
姓名 Imai, Shoichi
抄録
内容記述タイプ Abstract
内容記述 We have examined the effects of lacidipine, a new dihydropyridine calcium antagonist, on cardiohemodynamics in comparison with those of nifedipine. Experiments were performed in open- and close-chest dogs anesthetized with morphine-α-chloralose-urethane and nitrous oxide. Lacidipine and nifedipine were administered intravenously at 1~30μg/kg. In open-chest dogs, both lacidipine and nifedipine produced dose-dependent decreases in diastolic and mean blood pressures (DBP and MBP) and increases in heart rate (HR) and left ventricular max dP/dt (LV max dP/dt). The decrease in MBP produced by nifedipine was transient; the MBP recovered to a level almost equal to the predrug level in a few minutes. In contrast, the effects of lacidipine were more prolonged except at low dose levels. On the basis of half-life assessed at a dose causing a decrement of MBP of a similar magnitude the hypotensive effect of lacidipine was >9 times longer-lasting than that of nifedipine. Both nifedipine and lacidipine decreased systolic blood pressure (SBP), left ventricular pressure (LVP) and left ventricular end-diastolic pressure (LVEDP) and increased cardiac output (CO). Lacidipine and nifedipine decreased total peripheral resistance (TPR) dose-dependently. The decreases were 20~50% for lacidipine and 15~40 % for nifedipine. Coronary blood flow (Cor-F) was increased to 50~175 % of the control after lecidipine and coronary vascular resistance (Cor-R) was decreased to 25~75%, while the changes were 40~240% and 35~70% after nifedipine. Decreases and increases were dose-dependent with both drugs. The increases in Cor-F exceeded those expected from the increases in MVO_2 observed simultaneously. In close-chest dogs, both nifedipine and lacidipine increased carotid and femoral blood flow (Car-F and Fern-F) and dose-dependently decreased carotid and femoral vascular resistance (Car-R and Fem-R). Coincident with the fall in BP renal blood flow (Ren-F) was decreased. Renal vascular resistance (Ren-R) was slightly decreased at all doses except for the maximum dose, at which it increased. The changes observed in blood flow in these vascular beds were less than 50% at the maximum and those in vascular resistance were less than 35%. Changes in MBP and HR were similar to those observed in open-chest dogs. Duration of action of lacidipine was longer than that of nifedipine. Like nifedipine the action of lacidipine was selective towards coronary artery.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 108, 号 8, p. 593-608, 発行日 1994-08
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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