{"_buckets": {"deposit": "97f5946c-b6cc-413e-9b30-58d0d4c03f9f"}, "_deposit": {"id": "19180", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19180"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00019180"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Cardiohemodynamic Effects of Lacidipine, a Novel Calcium Antagonist"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1994-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageEnd": "608", "bibliographicPageStart": "593", "bibliographicVolumeNumber": "108", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "We have examined the effects of lacidipine, a new dihydropyridine calcium antagonist, on cardiohemodynamics in comparison with those of nifedipine. Experiments were performed in open- and close-chest dogs anesthetized with morphine-\u03b1-chloralose-urethane and nitrous oxide. Lacidipine and nifedipine were administered intravenously at 1\uff5e30\u03bcg/kg. In open-chest dogs, both lacidipine and nifedipine produced dose-dependent decreases in diastolic and mean blood pressures (DBP and MBP) and increases in heart rate (HR) and left ventricular max dP/dt (LV max dP/dt). The decrease in MBP produced by nifedipine was transient; the MBP recovered to a level almost equal to the predrug level in a few minutes. In contrast, the effects of lacidipine were more prolonged except at low dose levels. On the basis of half-life assessed at a dose causing a decrement of MBP of a similar magnitude the hypotensive effect of lacidipine was \u003e9 times longer-lasting than that of nifedipine. Both nifedipine and lacidipine decreased systolic blood pressure (SBP), left ventricular pressure (LVP) and left ventricular end-diastolic pressure (LVEDP) and increased cardiac output (CO). Lacidipine and nifedipine decreased total peripheral resistance (TPR) dose-dependently. The decreases were 20\uff5e50% for lacidipine and 15\uff5e40 % for nifedipine. Coronary blood flow (Cor-F) was increased to 50\uff5e175 % of the control after lecidipine and coronary vascular resistance (Cor-R) was decreased to 25\uff5e75%, while the changes were 40\uff5e240% and 35\uff5e70% after nifedipine. Decreases and increases were dose-dependent with both drugs. The increases in Cor-F exceeded those expected from the increases in MVO_2 observed simultaneously. In close-chest dogs, both nifedipine and lacidipine increased carotid and femoral blood flow (Car-F and Fern-F) and dose-dependently decreased carotid and femoral vascular resistance (Car-R and Fem-R). Coincident with the fall in BP renal blood flow (Ren-F) was decreased. Renal vascular resistance (Ren-R) was slightly decreased at all doses except for the maximum dose, at which it increased. The changes observed in blood flow in these vascular beds were less than 50% at the maximum and those in vascular resistance were less than 35%. Changes in MBP and HR were similar to those observed in open-chest dogs. Duration of action of lacidipine was longer than that of nifedipine. Like nifedipine the action of lacidipine was selective towards coronary artery.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "119448", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Hara, Katsutoshi"}]}, {"nameIdentifiers": [{"nameIdentifier": "119449", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Ishibashi, Takaharu"}]}, {"nameIdentifiers": [{"nameIdentifier": "119450", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Hamaguchi, Masami"}]}, {"nameIdentifiers": [{"nameIdentifier": "119451", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Imai, Shoichi"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u539f, \u52dd\u5229"}], "nameIdentifiers": [{"nameIdentifier": "119444", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u77f3\u6a4b, \u9686\u6cbb"}], "nameIdentifiers": [{"nameIdentifier": "119445", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u6ff1\u53e3, \u653f\u5df3"}], "nameIdentifiers": [{"nameIdentifier": "119446", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u4eca\u4e95, \u662d\u4e00"}], "nameIdentifiers": [{"nameIdentifier": "119447", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "108(8)_593-608.pdf", "filesize": [{"value": "2.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2400000.0, "url": {"label": "108(8)_593-608.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/19180/files/108(8)_593-608.pdf"}, "version_id": "5aa18969-3a59-4530-b764-1ec165054bde"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "lacidipine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "nifedipine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "calcium antagonist", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dog", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u85ac", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5fc3\u8840\u884c\u52d5\u614b", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5fc3\u7b4b\u9178\u7d20\u6d88\u8cbb\u91cf", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u65b0\u898f\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u85ac Lacidipine\u306e\u5fc3\u8840\u884c\u52d5\u614b\u306b\u5bfe\u3059\u308b\u4f5c\u7528", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u65b0\u898f\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u85ac Lacidipine\u306e\u5fc3\u8840\u884c\u52d5\u614b\u306b\u5bfe\u3059\u308b\u4f5c\u7528"}, {"subitem_title": "\u65b0\u898f\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u85ac Lacidipine\u306e\u5fc3\u8840\u884c\u52d5\u614b\u306b\u5bfe\u3059\u308b\u4f5c\u7528", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1147"], "permalink_uri": "http://hdl.handle.net/10191/38416", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-02-18"}, "publish_date": "2016-02-18", "publish_status": "0", "recid": "19180", "relation": {}, "relation_version_is_last": true, "title": ["\u65b0\u898f\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u85ac Lacidipine\u306e\u5fc3\u8840\u884c\u52d5\u614b\u306b\u5bfe\u3059\u308b\u4f5c\u7528"], "weko_shared_id": null}