{"created":"2021-03-01T06:23:41.749199+00:00","id":18893,"links":{},"metadata":{"_buckets":{"deposit":"310a605c-93c9-4bb4-aea4-226d3933e407"},"_deposit":{"id":"18893","owners":[],"pid":{"revision_id":0,"type":"depid","value":"18893"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00018893","sets":["453:456","471:537:538:1144"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Differentiation of Osteoclasts in Osteopetrotic (op) Mutant Mice Lacking Macrophage Colony-Stimulating Factor (M-CSF/CSF-1) Activity (Pathogenesis, Treatment and Prevention of Osteoporosis)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"814","bibliographicPageStart":"810","bibliographicVolumeNumber":"108","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ultrastructural and cytochemical features of osteoclasts of mice homozygous for the osteopetrosis (op/op) mutation were studies. The mutant mice are characterized by the prominent osteosclerosis and defective differentiation of osteoclasts, monocytes, and tissue macrophages due to a lack of functional macrophage colony-stimulating factor (M-CSF/CSF-1) activity. In op/op mice, osteoclalsts were markedly reduced and showed poorly developed ruffled borders. Daily administration of M-CSF induced the development and ultrastructural differentiation of osteoclasts, followed by the resorption of bones. These results indicate that the differentiation and proliferation of osteoclasts are mediated by M-CSF.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"117909","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Naito, Makoto"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"内藤, 眞"}],"nameIdentifiers":[{"nameIdentifier":"117908","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-08"}],"displaytype":"detail","filename":"108(11)_810-814.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"108(11)_810-814.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/18893/files/108(11)_810-814.pdf"},"version_id":"451a5a6d-6f6f-4580-ba50-6940d4d8fc22"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"osteoclasts","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophages","subitem_subject_scheme":"Other"},{"subitem_subject":"osteopetrotic mice","subitem_subject_scheme":"Other"},{"subitem_subject":"M-CSF (CSF-1)","subitem_subject_scheme":"Other"},{"subitem_subject":"破骨細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロファージ","subitem_subject_scheme":"Other"},{"subitem_subject":"大理石病マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロファージコロニー刺激因子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"2)大理石病モデルマウス(op/op)を用いた破骨細胞の分化機序の検討(シンポジウム 骨粗鬆症の病態・治療・予防, 第493回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"2)大理石病モデルマウス(op/op)を用いた破骨細胞の分化機序の検討(シンポジウム 骨粗鬆症の病態・治療・予防, 第493回新潟医学会)"},{"subitem_title":"2)大理石病モデルマウス(op/op)を用いた破骨細胞の分化機序の検討(シンポジウム 骨粗鬆症の病態・治療・予防, 第493回新潟医学会)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1144"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-29"},"publish_date":"2016-03-29","publish_status":"0","recid":"18893","relation_version_is_last":true,"title":["2)大理石病モデルマウス(op/op)を用いた破骨細胞の分化機序の検討(シンポジウム 骨粗鬆症の病態・治療・予防, 第493回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:49:58.244490+00:00"}