@article{oai:niigata-u.repo.nii.ac.jp:00018893,
 author = {内藤, 眞},
 issue = {11},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Nov},
 note = {Ultrastructural and cytochemical features of osteoclasts of mice homozygous for the osteopetrosis (op/op) mutation were studies. The mutant mice are characterized by the prominent osteosclerosis and defective differentiation of osteoclasts, monocytes, and tissue macrophages due to a lack of functional macrophage colony-stimulating factor (M-CSF/CSF-1) activity. In op/op mice, osteoclalsts were markedly reduced and showed poorly developed ruffled borders. Daily administration of M-CSF induced the development and ultrastructural differentiation of osteoclasts, followed by the resorption of bones. These results indicate that the differentiation and proliferation of osteoclasts are mediated by M-CSF.},
 pages = {810--814},
 title = {2)大理石病モデルマウス(op/op)を用いた破骨細胞の分化機序の検討(シンポジウム 骨粗鬆症の病態・治療・予防, 第493回新潟医学会)},
 volume = {108},
 year = {1994}
}