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2)大理石病モデルマウス(op/op)を用いた破骨細胞の分化機序の検討(シンポジウム 骨粗鬆症の病態・治療・予防, 第493回新潟医学会)
http://hdl.handle.net/10191/40472
http://hdl.handle.net/10191/40472048f3147-4dfe-4cdd-9291-ec199070089f
名前 / ファイル | ライセンス | アクション |
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108(11)_810-814.pdf (2.5 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-03-29 | |||||
タイトル | ||||||
タイトル | 2)大理石病モデルマウス(op/op)を用いた破骨細胞の分化機序の検討(シンポジウム 骨粗鬆症の病態・治療・予防, 第493回新潟医学会) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 2)大理石病モデルマウス(op/op)を用いた破骨細胞の分化機序の検討(シンポジウム 骨粗鬆症の病態・治療・予防, 第493回新潟医学会) | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | osteoclasts | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | macrophages | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | osteopetrotic mice | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | M-CSF (CSF-1) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 破骨細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | マクロファージ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 大理石病マウス | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | マクロファージコロニー刺激因子 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Differentiation of Osteoclasts in Osteopetrotic (op) Mutant Mice Lacking Macrophage Colony-Stimulating Factor (M-CSF/CSF-1) Activity (Pathogenesis, Treatment and Prevention of Osteoporosis) | |||||
著者 |
内藤, 眞
× 内藤, 眞 |
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著者別名 | ||||||
識別子 | 117909 | |||||
識別子Scheme | WEKO | |||||
姓名 | Naito, Makoto | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Ultrastructural and cytochemical features of osteoclasts of mice homozygous for the osteopetrosis (op/op) mutation were studies. The mutant mice are characterized by the prominent osteosclerosis and defective differentiation of osteoclasts, monocytes, and tissue macrophages due to a lack of functional macrophage colony-stimulating factor (M-CSF/CSF-1) activity. In op/op mice, osteoclalsts were markedly reduced and showed poorly developed ruffled borders. Daily administration of M-CSF induced the development and ultrastructural differentiation of osteoclasts, followed by the resorption of bones. These results indicate that the differentiation and proliferation of osteoclasts are mediated by M-CSF. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 108, 号 11, p. 810-814, 発行日 1994-11 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |