@article{oai:niigata-u.repo.nii.ac.jp:00018890,
 author = {末山, 博男 and 酒井, 邦夫 and 関, 裕史 and 杉田, 公 and 土田, 恵美子 and 伊藤, 猛 and 松本, 康男 and 中野, 政雄},
 issue = {11},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Nov},
 note = {The standard treatment for locally advanced cervical cancer is primarily radiation therapy alone. However, the treatment results, in terms of local control and survival, have not come to an acceptable level. In FIGO stage III, IV, the 5-year survival rate ranged from 35～53 % and 0～29 %, respectively. An analysis of patterns of failure demonstrated that a majority of patients firstly developed pelvic failure, secondly distant failure. Additionally within the same stage the more the volume increase, the more difficult it becomes to control the lesion. Thus strategies for proving the treatment resuluts of locally advanced cervical caricinoma are necessary to raise pelvic control rate. In an efforts to improve these results, many investigaters tried combined treatment, such as hypoxic radiosensitizers, hyperthermia, interstitial therapy and fast neutron therapy. Unfortunately these approaches have shown little improvement in local tumor control. Carcinoma of the cervix has been found to have a moderate chemosensitive tumor. The rationale for using intra-arterial (I-A) chemotherapy is to increase the drug concentration in the tumor tissue and to decrease the systemic toxicity. There are two fashions in I-A chemotherapy. Many reports indicated that I-A chemotherapy with neoadjuvant or concomitant modality produced good initial response but there were few reports that I-A chemotherapy improved survival. To evaluate the role of I-A chemotherapy in the management of advanced cervical carcinoma, the further study and an extended observation period are needed.},
 pages = {787--797},
 title = {局所進行子宮頸癌に対する放射線治療と動注化学療法の併用療法},
 volume = {108},
 year = {1994}
}