@article{oai:niigata-u.repo.nii.ac.jp:00018853, author = {中村, 宏志 and 伊藤, 正毅 and 柴田, 昭}, issue = {12}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Dec}, note = {Previously, it has been reported that a low protein diet prevents the progression of diabetic nephropathy. Low protein alimentation can reduce proteinuria in patients with moderate diabetic nephropathy (serum creatinine ≦ 2.0 mg/dl). However, dietary protein restriction may cause muscle wasting or malnutrition. In a previous report, we examined the influence of proteins from different sources on renal function in healthy volunteers and diabetic patients. Our study showed that ingestion of egg white, cheese or cooked soybean protein did not affect GFR or AER (albumin excretion rate). GFR rose significantly and AER did not change after ingestion of tuna fish. Either GFR or AER rose after ingestion of cooked pork or beef. Urinary 6-keto-PGF_1α excetion increased after ingestion of pork, beef or tuna fish. Urinary TXB_2 excretion increased after pork or beef loading. Our findings suggest that certain kinds of protein can be excepted from dietary portein restriction. Our study involved only acute loading, and prolonged clinical study is necessary to evaluate this possibility and safety.}, pages = {897--901}, title = {6)低蛋白食の適応と食事性蛋白質の扱い(シンポジウム 糖尿病研究の進歩と治療, 第498回新潟医学会)}, volume = {108}, year = {1994} }