@article{oai:niigata-u.repo.nii.ac.jp:00018849,
 author = {谷, 長行 and 山崎, 雅俊 and 宇佐美, 明男 and 伊藤, 正毅 and 柴田, 昭 and 佐藤, 巌},
 issue = {12},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Dec},
 note = {As to effect of glycemic control on diabetic complication, DCCT (Diabetes Control and Care Trial) research group reported that strict glycemic control could prevent and intervent diabetic retinopathy and nephropathy. Importance of blood pressure control is also recognized in prevention of retinopathy and nephropathy, although it has been well recognized in ischemic heart disease. We studied the mechanism of endothelial cell damage in diabetic patients using soluble thrombomodulin (sTM) concentration as endothelial cell marker. No correlation was found between sTM and HbA1c in diabetic patients without any complications, although high sTM concentrations were found in patients with HbA1c of more than 6 %. Short-term glycemic control could not reduce sTM concentration in the diabetic patients. Oral administration of aldose reductase inhibitor, Eparlestat, for four weeks could not reduce sTM in diabetic patients. In conclusin, hyperglycemia itself dose not seem to cause the endothelial cell damage directly in diabetes mellitus.},
 pages = {879--883},
 title = {2)合併症の進展と血糖コントロールの効果と限界(シンポジウム 糖尿病研究の進歩と治療, 第498回新潟医学会)},
 volume = {108},
 year = {1994}
}