@article{oai:niigata-u.repo.nii.ac.jp:00018781,
 author = {小田野, 行男 and 宮下, 光太郎 and 蓑島, 聡 and 中島, 孝 and 藤田, 基 and 生田, 房弘},
 issue = {1},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jan},
 note = {To determine whether low functional but viable neurons are represented by a technique for in-vivo neuroreceptor imaging, we did experiments in gerbils with cerebral infarction, in which we examined its histological changes and findings of dual tracer in-vivo autoradiography of glucose utilization with [＾<14>C]-deoxyglucose and benzodiazepine receptor binding with [＾<123>I]-iomazenil. The uncoupled findings of cerebral glucose metabolism and benzodiazepine receptor bindings were observed in the primary infarct lesion and in remote areas including the ipsilateral striatum and thalamus. Our experiments show that when the viable neurons with low functional activity remains intact, its situation can be demonstrated as normal in-vivo binding of benzodiazepine receptors with hypometabolism of glucose utilization. This functional contrast enhanced technique with [＾<123>I]-iomazenil may play an important role to predict neuronal cell viability after recent brain infarction in experimented animals and humans with single photon emission computed tomography. The clinical usefulness of [＾<123>I]-iomazenil and SPECT was also proposed in the diagnosis of the patients with chronic cerebral infarction and Parkinson's disease.},
 pages = {1--7},
 title = {SPECTによる脳の新しい画像診断法の研究 : [^<123>I]-Iomazenilによる中枢性ベンゾジアゼピン受容体イメージング},
 volume = {109},
 year = {1995}
}