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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第109巻第1号

SPECTによる脳の新しい画像診断法の研究 : [^<123>I]-Iomazenilによる中枢性ベンゾジアゼピン受容体イメージング

http://hdl.handle.net/10191/41975
http://hdl.handle.net/10191/41975
2917354e-1806-42d2-97ad-b203dd56f178
名前 / ファイル ライセンス アクション
109(1)_1-7.pdf 109(1)_1-7.pdf (1.4 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-05-25
タイトル
タイトル SPECTによる脳の新しい画像診断法の研究 : [^<123>I]-Iomazenilによる中枢性ベンゾジアゼピン受容体イメージング
タイトル
言語 en
タイトル SPECTによる脳の新しい画像診断法の研究 : [^<123>I]-Iomazenilによる中枢性ベンゾジアゼピン受容体イメージング
言語
言語 jpn
キーワード
主題Scheme Other
主題 Benzodiazepine receptor
キーワード
主題Scheme Other
主題 Glucose metabolism
キーワード
主題Scheme Other
主題 Neuronal cell viability
キーワード
主題Scheme Other
主題 [^<123>I]-Ro 16-0154 (Iomazenil)
キーワード
主題Scheme Other
主題 Parkinson's disease
キーワード
主題Scheme Other
主題 ベンゾジアゼピン受容体
キーワード
主題Scheme Other
主題 ^<123>I-イオマゼニール
キーワード
主題Scheme Other
主題 グルコース代謝
キーワード
主題Scheme Other
主題 神経細胞
キーワード
主題Scheme Other
主題 生存能
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル A New SPECT Ligand for Benzodiazepine Receptor Mapping with [^<123>I]-Iomazenil and its Clinical Usefulness in SPECT Studies
著者 小田野, 行男

× 小田野, 行男

WEKO 117279

小田野, 行男

Search repository
宮下, 光太郎

× 宮下, 光太郎

WEKO 117280

宮下, 光太郎

Search repository
蓑島, 聡

× 蓑島, 聡

WEKO 117281

蓑島, 聡

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中島, 孝

× 中島, 孝

WEKO 117282

中島, 孝

Search repository
藤田, 基

× 藤田, 基

WEKO 117283

藤田, 基

Search repository
生田, 房弘

× 生田, 房弘

WEKO 117284

生田, 房弘

Search repository
著者別名
識別子 117285
識別子Scheme WEKO
姓名 Odano, Ikuo
著者別名
識別子 117286
識別子Scheme WEKO
姓名 Miyashita, Kohtaro
著者別名
識別子 117287
識別子Scheme WEKO
姓名 Minoshima, Satosi
著者別名
識別子 117288
識別子Scheme WEKO
姓名 Nakajima, Takashi
著者別名
識別子 117289
識別子Scheme WEKO
姓名 Fujita, Motoi
著者別名
識別子 117290
識別子Scheme WEKO
姓名 Ikuta, Fusahiro
抄録
内容記述タイプ Abstract
内容記述 To determine whether low functional but viable neurons are represented by a technique for in-vivo neuroreceptor imaging, we did experiments in gerbils with cerebral infarction, in which we examined its histological changes and findings of dual tracer in-vivo autoradiography of glucose utilization with [^<14>C]-deoxyglucose and benzodiazepine receptor binding with [^<123>I]-iomazenil. The uncoupled findings of cerebral glucose metabolism and benzodiazepine receptor bindings were observed in the primary infarct lesion and in remote areas including the ipsilateral striatum and thalamus. Our experiments show that when the viable neurons with low functional activity remains intact, its situation can be demonstrated as normal in-vivo binding of benzodiazepine receptors with hypometabolism of glucose utilization. This functional contrast enhanced technique with [^<123>I]-iomazenil may play an important role to predict neuronal cell viability after recent brain infarction in experimented animals and humans with single photon emission computed tomography. The clinical usefulness of [^<123>I]-iomazenil and SPECT was also proposed in the diagnosis of the patients with chronic cerebral infarction and Parkinson's disease.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 109, 号 1, p. 1-7, 発行日 1995-01
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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