WEKO3
アイテム
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SPECTによる脳の新しい画像診断法の研究 : [^<123>I]-Iomazenilによる中枢性ベンゾジアゼピン受容体イメージング
http://hdl.handle.net/10191/41975
http://hdl.handle.net/10191/419752917354e-1806-42d2-97ad-b203dd56f178
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-05-25 | |||||
タイトル | ||||||
タイトル | SPECTによる脳の新しい画像診断法の研究 : [^<123>I]-Iomazenilによる中枢性ベンゾジアゼピン受容体イメージング | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | SPECTによる脳の新しい画像診断法の研究 : [^<123>I]-Iomazenilによる中枢性ベンゾジアゼピン受容体イメージング | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Benzodiazepine receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Glucose metabolism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Neuronal cell viability | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | [^<123>I]-Ro 16-0154 (Iomazenil) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Parkinson's disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ベンゾジアゼピン受容体 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ^<123>I-イオマゼニール | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | グルコース代謝 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 神経細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 生存能 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | A New SPECT Ligand for Benzodiazepine Receptor Mapping with [^<123>I]-Iomazenil and its Clinical Usefulness in SPECT Studies | |||||
著者 |
小田野, 行男
× 小田野, 行男× 宮下, 光太郎× 蓑島, 聡× 中島, 孝× 藤田, 基× 生田, 房弘 |
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著者別名 | ||||||
識別子 | 117285 | |||||
識別子Scheme | WEKO | |||||
姓名 | Odano, Ikuo | |||||
著者別名 | ||||||
識別子 | 117286 | |||||
識別子Scheme | WEKO | |||||
姓名 | Miyashita, Kohtaro | |||||
著者別名 | ||||||
識別子 | 117287 | |||||
識別子Scheme | WEKO | |||||
姓名 | Minoshima, Satosi | |||||
著者別名 | ||||||
識別子 | 117288 | |||||
識別子Scheme | WEKO | |||||
姓名 | Nakajima, Takashi | |||||
著者別名 | ||||||
識別子 | 117289 | |||||
識別子Scheme | WEKO | |||||
姓名 | Fujita, Motoi | |||||
著者別名 | ||||||
識別子 | 117290 | |||||
識別子Scheme | WEKO | |||||
姓名 | Ikuta, Fusahiro | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To determine whether low functional but viable neurons are represented by a technique for in-vivo neuroreceptor imaging, we did experiments in gerbils with cerebral infarction, in which we examined its histological changes and findings of dual tracer in-vivo autoradiography of glucose utilization with [^<14>C]-deoxyglucose and benzodiazepine receptor binding with [^<123>I]-iomazenil. The uncoupled findings of cerebral glucose metabolism and benzodiazepine receptor bindings were observed in the primary infarct lesion and in remote areas including the ipsilateral striatum and thalamus. Our experiments show that when the viable neurons with low functional activity remains intact, its situation can be demonstrated as normal in-vivo binding of benzodiazepine receptors with hypometabolism of glucose utilization. This functional contrast enhanced technique with [^<123>I]-iomazenil may play an important role to predict neuronal cell viability after recent brain infarction in experimented animals and humans with single photon emission computed tomography. The clinical usefulness of [^<123>I]-iomazenil and SPECT was also proposed in the diagnosis of the patients with chronic cerebral infarction and Parkinson's disease. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 109, 号 1, p. 1-7, 発行日 1995-01 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |