@article{oai:niigata-u.repo.nii.ac.jp:00018165, author = {草野, 頼子}, issue = {4}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Apr}, note = {The efficacy of class III antiarrhythmic drugs to recurrent sustained ventricular tachycardia (VT) was examined. In 18 patients, monomorphic VT was induced and rapid ventricular pacing was attempted at progressively shorter cycle length until VT was terminated at a critical cycle length (=block cycle, length). The width of zone of entrainment was caluculated as the difference between the cycle length of VT, and the block cycle length and used as an index of the excitable gap. After administration of amiodarone or dl-sotalol, drug efficacy was evaluated in serial electrophysiologic studies. The basal electrophysiologic parameters were compared between the responders in which VT was not inducible and the non-responders in which VT remained inducible during therapy with class III drugs. In 8 patients, VT was not induced, and 10 patients failed during drug therapy with class III drugs. The cycle length of VT, the block cycle length or width of zone of entrainment was not different between the two groups. However the effective refractory period measured in the normal myocardium was prolonged significantly only in the responders.}, pages = {136--143}, title = {持続性心室頻拍のリエントリー回路に対するIII群抗不整脈薬の作用と誘発阻止の関係}, volume = {110}, year = {1996} }