@article{oai:niigata-u.repo.nii.ac.jp:00018118,
 author = {佐久間, 一弘},
 issue = {5},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {May},
 note = {The effects of human and porcine polymorphonuclear leukocytes (h-and p-PMLs) on coronary arterial tone were studied using ring segments of the branches of left anterier descending arteries (diam. 1.0～1.3mm, length 2.0mm) isolated from the pig. PMLs (10^6 cells/ml) reduced the tone of the endothelium-intact preparations contracted with 5×10^<-10>-3×10＾<-9>M endothelin-1 (ET-1) to a greater extent than that of endothelium-denued ones. The PMLs-induced relaxation of the endothelium-intact preparations were not influenced by various antagonists or inhibitors of nitric oxide production, potassium channel, arachidonate cascade, and adenocine triphosphate dehydroxygenase. However, the relaxation by h-and p-PMLs were almost abolished in preparations treated with Na＾+-K＾+-ATP-ase inhibitor, 5×10＾<-6>M ouabain and contracted with potassium chloride. The findings suggest that neither nitric oxide nor eicosanoids account for the h-and p-PMLs-induced relaxation of porcine coronary artery. It appears that other endothelium derived relaxing factors, such as endothelium derived hyperpolarizing factor, may be involved in the PMLs-induced relaxation.},
 pages = {177--183},
 title = {ブタ冠状動脈の多核白血球による内皮依存性弛緩作用},
 volume = {110},
 year = {1996}
}