{"created":"2021-03-01T06:22:48.275005+00:00","id":18075,"links":{},"metadata":{"_buckets":{"deposit":"958a9040-61c9-4086-975b-27f7f88bd497"},"_deposit":{"id":"18075","owners":[],"pid":{"revision_id":0,"type":"depid","value":"18075"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00018075","sets":["453:456","471:537:538:1128"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Examination of Exacerbating Factors in Diabetic Retinopathy"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"248","bibliographicPageStart":"239","bibliographicVolumeNumber":"110","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To examine exacerbating factors in diabetic retinopathy, we retrospectively evaluated clinical findings on long-term follow up of 183 patients with non-insulin dependent diabetes mellitus (NIDDM)(93 males, 90 females). I) Diabetic retinopathy was classified as no retinopathy, simple, preproliferative and proliferative retinopathy. The patients were divided into 3 groups: an exacerbated group with at least 1 stage of progression, a stable group without progression, and an improved group with at least 1 stage of improvement over the past 5 years. The mean value of hemoglobin A1c (HbA1c) and mean blood pressure during the past 5 years were examined among 3 groups. II) 45 patients with simple retinopathy (22 males, 23 females) were divided into 2 groups, an exacerbated group or a stable/improved group, and were studied as described in I). III) 23 patients (8 males, 15 females) with NIDDM in whom the onset of simple retinopathy could be specified, were divided into 2 groups, Group S with simple retinopathy without progression or Group P with progression from simple retinopathy to either preproliferative or proliferative retinopathy. The following items were retrospectively compared: 1. duration of simple retinopathy (prior to study), 2. HbA1c, 3. systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean blood pressure (MBP), and 4. serum total cholesterol (TC). The results are as follows: I There were 23 patients in the improvement group, 106 patients in the no change group, and 54 patients in the exacerbation group. In both the improvement group and the no change group, levels of HbA1c and mean blood pressure were significantly lower than those in the exacerbation group (p<0.001). II There were 24 patients in the improvement/no change group, and 21 patients in the exacerbation group. In the improvement/no change group, levels of HbA1c and mean blood pressure were significantly lower than those in the exacerbation group (p<0.01, p<0.001). III There were significant differences in the duration of simple retinopathy, the HbA1c value and the TC concentration between Group S and P. There was no significant difference in other items. In conclusion, degree of HbA1c level was considered to be an important exacerbating factor in diabetic retinopathy. Furthermore, involvement of hypertension before the onset of retinopathy is suggested, although we cannot over look the possibility that levels of blood pressure was due to diabetic nephropathy. In addition to control of blood glucose and serum hypercholestelonemia, early treatment for hypertension may be important to prevent progression of retinopathy.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"113465","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nakagawa, Osamu"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中川, 理"}],"nameIdentifiers":[{"nameIdentifier":"113464","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-08"}],"displaytype":"detail","filename":"110(6)_239-248.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110(6)_239-248.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/18075/files/110(6)_239-248.pdf"},"version_id":"3b7b1178-1634-4ed7-aa3e-4c56ddb6f8fd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"NIDDM","subitem_subject_scheme":"Other"},{"subitem_subject":"Diabetic retinopathy","subitem_subject_scheme":"Other"},{"subitem_subject":"HbA1c","subitem_subject_scheme":"Other"},{"subitem_subject":"増悪因子","subitem_subject_scheme":"Other"},{"subitem_subject":"高血圧","subitem_subject_scheme":"Other"},{"subitem_subject":"罹病期間","subitem_subject_scheme":"Other"},{"subitem_subject":"血清コレステロール","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"糖尿病性網膜症の増悪因子の検討 : 過去5年間の臨床データより","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"糖尿病性網膜症の増悪因子の検討 : 過去5年間の臨床データより"},{"subitem_title":"糖尿病性網膜症の増悪因子の検討 : 過去5年間の臨床データより","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1128"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-08"},"publish_date":"2016-08-08","publish_status":"0","recid":"18075","relation_version_is_last":true,"title":["糖尿病性網膜症の増悪因子の検討 : 過去5年間の臨床データより"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:49:18.958021+00:00"}