{"created":"2021-03-01T06:22:48.016931+00:00","id":18071,"links":{},"metadata":{"_buckets":{"deposit":"477a3d88-09c8-4404-9cba-c1027726f446"},"_deposit":{"id":"18071","owners":[],"pid":{"revision_id":0,"type":"depid","value":"18071"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00018071","sets":["453:456","471:537:538:1128"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"A Cruicial Role of CD8-Positive Lymphocytes in Enhancement of ICAM-1 Expression on Glomerular Endothelial Cells in Crescentic Glomerulonephritis of WKY Rats (Recent Topics in Vascular Biology)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"212","bibliographicPageStart":"210","bibliographicVolumeNumber":"110","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CD8-positive lymphocytes (CD8^+lym) and ICAM-1/LFA-1 interaction have been implicated in the glomerular accumulation of monocytes/macrophages (Mo/Mφ) and crescent formation in anti-glomerular basement membrane (GBM) glomerulonephritis of WKY rats. In the present study, the participation of CD8^+lym and inflammatory cytokines in the expression of ICAM-1 and the accumulation of Mo/Mφ in the glomeruli was examined. ICAM-1 expression and Mo/Mφ accumulation were markedly enhanced in the glomeruli after anti-GBM antibody injection. By depleting the CD8^+lym in the circulation, the increased expression of ICAM-1 and glomerular accumulation of Mo/Mφ were suppressed, indicating a crucial role of CD8^+lym in the enhancement of ICAM-1 expression and the Mo/Mφ accumulation. Expression of mRNA for IL-1β, TNFα and IFNγ, known to enhance ICAM-1 expression, was induced in the glomeruli at a mRNA level in a similar profile to that of ICAM-1 expression. The CD8^+lym depletion also suppressed the induction of mRNA expression for these cytokines except for IL-1β. These results indicate CD8^+lym up-regulate the expression of ICAM-1 probably through induction of TNFα and IFNγ and play a role in the accumulate Mo/Mφ.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"113448","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Fujinaka, Hidehiko"}]},{"nameIdentifiers":[{"nameIdentifier":"113449","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yamamoto, Tadashi"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤中, 秀彦"}],"nameIdentifiers":[{"nameIdentifier":"113446","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本, 格"}],"nameIdentifiers":[{"nameIdentifier":"113447","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-08"}],"displaytype":"detail","filename":"110(6)_210-212.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110(6)_210-212.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/18071/files/110(6)_210-212.pdf"},"version_id":"f81add3f-1cb6-4205-9ab3-6fd390764246"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"anti-GBM nephritis","subitem_subject_scheme":"Other"},{"subitem_subject":"glomerular endothelial cell","subitem_subject_scheme":"Other"},{"subitem_subject":"CD8-positive lymphocyte","subitem_subject_scheme":"Other"},{"subitem_subject":"ICAM-1","subitem_subject_scheme":"Other"},{"subitem_subject":"cytokine","subitem_subject_scheme":"Other"},{"subitem_subject":"抗糸球体基底膜型腎炎","subitem_subject_scheme":"Other"},{"subitem_subject":"糸球体内皮細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"CD8 陽性リンパ球","subitem_subject_scheme":"Other"},{"subitem_subject":"サイトカイン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"4) 実験腎炎における白血球集積機序 : CD8陽性リンパ球による糸球体内皮細胞のICAM-1発現促進(シンポジウム 血管細胞生物学の進歩, 第517回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"4) 実験腎炎における白血球集積機序 : CD8陽性リンパ球による糸球体内皮細胞のICAM-1発現促進(シンポジウム 血管細胞生物学の進歩, 第517回新潟医学会)"},{"subitem_title":"4) 実験腎炎における白血球集積機序 : CD8陽性リンパ球による糸球体内皮細胞のICAM-1発現促進(シンポジウム 血管細胞生物学の進歩, 第517回新潟医学会)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1128"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-08"},"publish_date":"2016-08-08","publish_status":"0","recid":"18071","relation_version_is_last":true,"title":["4) 実験腎炎における白血球集積機序 : CD8陽性リンパ球による糸球体内皮細胞のICAM-1発現促進(シンポジウム 血管細胞生物学の進歩, 第517回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:49:19.391466+00:00"}