{"_buckets": {"deposit": "477a3d88-09c8-4404-9cba-c1027726f446"}, "_deposit": {"id": "18071", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "18071"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00018071"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "A Cruicial Role of CD8-Positive Lymphocytes in Enhancement of ICAM-1 Expression on Glomerular Endothelial Cells in Crescentic Glomerulonephritis of WKY Rats (Recent Topics in Vascular Biology)"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1996-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "212", "bibliographicPageStart": "210", "bibliographicVolumeNumber": "110", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "CD8-positive lymphocytes (CD8^+lym) and ICAM-1/LFA-1 interaction have been implicated in the glomerular accumulation of monocytes/macrophages (Mo/M\u03c6) and crescent formation in anti-glomerular basement membrane (GBM) glomerulonephritis of WKY rats. In the present study, the participation of CD8^+lym and inflammatory cytokines in the expression of ICAM-1 and the accumulation of Mo/M\u03c6 in the glomeruli was examined. ICAM-1 expression and Mo/M\u03c6 accumulation were markedly enhanced in the glomeruli after anti-GBM antibody injection. By depleting the CD8^+lym in the circulation, the increased expression of ICAM-1 and glomerular accumulation of Mo/M\u03c6 were suppressed, indicating a crucial role of CD8^+lym in the enhancement of ICAM-1 expression and the Mo/M\u03c6 accumulation. Expression of mRNA for IL-1\u03b2, TNF\u03b1 and IFN\u03b3, known to enhance ICAM-1 expression, was induced in the glomeruli at a mRNA level in a similar profile to that of ICAM-1 expression. The CD8^+lym depletion also suppressed the induction of mRNA expression for these cytokines except for IL-1\u03b2. These results indicate CD8^+lym up-regulate the expression of ICAM-1 probably through induction of TNF\u03b1 and IFN\u03b3 and play a role in the accumulate Mo/M\u03c6.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "113448", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Fujinaka, Hidehiko"}]}, {"nameIdentifiers": [{"nameIdentifier": "113449", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Yamamoto, Tadashi"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u85e4\u4e2d, \u79c0\u5f66"}], "nameIdentifiers": [{"nameIdentifier": "113446", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u5c71\u672c, \u683c"}], "nameIdentifiers": [{"nameIdentifier": "113447", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "110(6)_210-212.pdf", "filesize": [{"value": "3.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3200000.0, "url": {"label": "110(6)_210-212.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/18071/files/110(6)_210-212.pdf"}, "version_id": "f81add3f-1cb6-4205-9ab3-6fd390764246"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "anti-GBM nephritis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "glomerular endothelial cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD8-positive lymphocyte", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ICAM-1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cytokine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u6297\u7cf8\u7403\u4f53\u57fa\u5e95\u819c\u578b\u814e\u708e", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u7cf8\u7403\u4f53\u5185\u76ae\u7d30\u80de", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD8 \u967d\u6027\u30ea\u30f3\u30d1\u7403", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "4) \u5b9f\u9a13\u814e\u708e\u306b\u304a\u3051\u308b\u767d\u8840\u7403\u96c6\u7a4d\u6a5f\u5e8f : CD8\u967d\u6027\u30ea\u30f3\u30d1\u7403\u306b\u3088\u308b\u7cf8\u7403\u4f53\u5185\u76ae\u7d30\u80de\u306eICAM-1\u767a\u73fe\u4fc3\u9032(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u8840\u7ba1\u7d30\u80de\u751f\u7269\u5b66\u306e\u9032\u6b69, \u7b2c517\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "4) \u5b9f\u9a13\u814e\u708e\u306b\u304a\u3051\u308b\u767d\u8840\u7403\u96c6\u7a4d\u6a5f\u5e8f : CD8\u967d\u6027\u30ea\u30f3\u30d1\u7403\u306b\u3088\u308b\u7cf8\u7403\u4f53\u5185\u76ae\u7d30\u80de\u306eICAM-1\u767a\u73fe\u4fc3\u9032(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u8840\u7ba1\u7d30\u80de\u751f\u7269\u5b66\u306e\u9032\u6b69, \u7b2c517\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"}, {"subitem_title": "4) \u5b9f\u9a13\u814e\u708e\u306b\u304a\u3051\u308b\u767d\u8840\u7403\u96c6\u7a4d\u6a5f\u5e8f : CD8\u967d\u6027\u30ea\u30f3\u30d1\u7403\u306b\u3088\u308b\u7cf8\u7403\u4f53\u5185\u76ae\u7d30\u80de\u306eICAM-1\u767a\u73fe\u4fc3\u9032(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u8840\u7ba1\u7d30\u80de\u751f\u7269\u5b66\u306e\u9032\u6b69, \u7b2c517\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1128"], "permalink_uri": "http://hdl.handle.net/10191/43113", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-08-08"}, "publish_date": "2016-08-08", "publish_status": "0", "recid": "18071", "relation": {}, "relation_version_is_last": true, "title": ["4) \u5b9f\u9a13\u814e\u708e\u306b\u304a\u3051\u308b\u767d\u8840\u7403\u96c6\u7a4d\u6a5f\u5e8f : CD8\u967d\u6027\u30ea\u30f3\u30d1\u7403\u306b\u3088\u308b\u7cf8\u7403\u4f53\u5185\u76ae\u7d30\u80de\u306eICAM-1\u767a\u73fe\u4fc3\u9032(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u8840\u7ba1\u7d30\u80de\u751f\u7269\u5b66\u306e\u9032\u6b69, \u7b2c517\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"], "weko_shared_id": null}