{"_buckets": {"deposit": "477a3d88-09c8-4404-9cba-c1027726f446"}, "_deposit": {"id": "18071", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "18071"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00018071", "sets": ["456", "1128"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "A Cruicial Role of CD8-Positive Lymphocytes in Enhancement of ICAM-1 Expression on Glomerular Endothelial Cells in Crescentic Glomerulonephritis of WKY Rats (Recent Topics in Vascular Biology)"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1996-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "212", "bibliographicPageStart": "210", "bibliographicVolumeNumber": "110", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "CD8-positive lymphocytes (CD8^+lym) and ICAM-1/LFA-1 interaction have been implicated in the glomerular accumulation of monocytes/macrophages (Mo/Mφ) and crescent formation in anti-glomerular basement membrane (GBM) glomerulonephritis of WKY rats. In the present study, the participation of CD8^+lym and inflammatory cytokines in the expression of ICAM-1 and the accumulation of Mo/Mφ in the glomeruli was examined. ICAM-1 expression and Mo/Mφ accumulation were markedly enhanced in the glomeruli after anti-GBM antibody injection. By depleting the CD8^+lym in the circulation, the increased expression of ICAM-1 and glomerular accumulation of Mo/Mφ were suppressed, indicating a crucial role of CD8^+lym in the enhancement of ICAM-1 expression and the Mo/Mφ accumulation. Expression of mRNA for IL-1β, TNFα and IFNγ, known to enhance ICAM-1 expression, was induced in the glomeruli at a mRNA level in a similar profile to that of ICAM-1 expression. The CD8^+lym depletion also suppressed the induction of mRNA expression for these cytokines except for IL-1β. These results indicate CD8^+lym up-regulate the expression of ICAM-1 probably through induction of TNFα and IFNγ and play a role in the accumulate Mo/Mφ.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "113448", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Fujinaka, Hidehiko"}]}, {"nameIdentifiers": [{"nameIdentifier": "113449", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Yamamoto, Tadashi"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "藤中, 秀彦"}], "nameIdentifiers": [{"nameIdentifier": "113446", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山本, 格"}], "nameIdentifiers": [{"nameIdentifier": "113447", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "110(6)_210-212.pdf", "filesize": [{"value": "3.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3200000.0, "url": {"label": "110(6)_210-212.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/18071/files/110(6)_210-212.pdf"}, "version_id": "f81add3f-1cb6-4205-9ab3-6fd390764246"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "anti-GBM nephritis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "glomerular endothelial cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD8-positive lymphocyte", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ICAM-1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cytokine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "抗糸球体基底膜型腎炎", "subitem_subject_scheme": "Other"}, {"subitem_subject": "糸球体内皮細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD8 陽性リンパ球", "subitem_subject_scheme": "Other"}, {"subitem_subject": "サイトカイン", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "4) 実験腎炎における白血球集積機序 : CD8陽性リンパ球による糸球体内皮細胞のICAM-1発現促進(シンポジウム 血管細胞生物学の進歩, 第517回新潟医学会)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "4) 実験腎炎における白血球集積機序 : CD8陽性リンパ球による糸球体内皮細胞のICAM-1発現促進(シンポジウム 血管細胞生物学の進歩, 第517回新潟医学会)"}, {"subitem_title": "4) 実験腎炎における白血球集積機序 : CD8陽性リンパ球による糸球体内皮細胞のICAM-1発現促進(シンポジウム 血管細胞生物学の進歩, 第517回新潟医学会)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1128"], "permalink_uri": "http://hdl.handle.net/10191/43113", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-08-08"}, "publish_date": "2016-08-08", "publish_status": "0", "recid": "18071", "relation": {}, "relation_version_is_last": true, "title": ["4) 実験腎炎における白血球集積機序 : CD8陽性リンパ球による糸球体内皮細胞のICAM-1発現促進(シンポジウム 血管細胞生物学の進歩, 第517回新潟医学会)"], "weko_shared_id": null}