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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第110巻第6号

4) 実験腎炎における白血球集積機序 : CD8陽性リンパ球による糸球体内皮細胞のICAM-1発現促進(シンポジウム 血管細胞生物学の進歩, 第517回新潟医学会)

http://hdl.handle.net/10191/43113
http://hdl.handle.net/10191/43113
c7173623-75bb-4795-9518-32787a6f79f0
名前 / ファイル ライセンス アクション
110(6)_210-212.pdf 110(6)_210-212.pdf (3.2 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-08-08
タイトル
タイトル 4) 実験腎炎における白血球集積機序 : CD8陽性リンパ球による糸球体内皮細胞のICAM-1発現促進(シンポジウム 血管細胞生物学の進歩, 第517回新潟医学会)
タイトル
言語 en
タイトル 4) 実験腎炎における白血球集積機序 : CD8陽性リンパ球による糸球体内皮細胞のICAM-1発現促進(シンポジウム 血管細胞生物学の進歩, 第517回新潟医学会)
言語
言語 jpn
キーワード
主題Scheme Other
主題 anti-GBM nephritis
キーワード
主題Scheme Other
主題 glomerular endothelial cell
キーワード
主題Scheme Other
主題 CD8-positive lymphocyte
キーワード
主題Scheme Other
主題 ICAM-1
キーワード
主題Scheme Other
主題 cytokine
キーワード
主題Scheme Other
主題 抗糸球体基底膜型腎炎
キーワード
主題Scheme Other
主題 糸球体内皮細胞
キーワード
主題Scheme Other
主題 CD8 陽性リンパ球
キーワード
主題Scheme Other
主題 サイトカイン
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル A Cruicial Role of CD8-Positive Lymphocytes in Enhancement of ICAM-1 Expression on Glomerular Endothelial Cells in Crescentic Glomerulonephritis of WKY Rats (Recent Topics in Vascular Biology)
著者 藤中, 秀彦

× 藤中, 秀彦

WEKO 113446

藤中, 秀彦

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山本, 格

× 山本, 格

WEKO 113447

山本, 格

Search repository
著者別名
識別子 113448
識別子Scheme WEKO
姓名 Fujinaka, Hidehiko
著者別名
識別子 113449
識別子Scheme WEKO
姓名 Yamamoto, Tadashi
抄録
内容記述タイプ Abstract
内容記述 CD8-positive lymphocytes (CD8^+lym) and ICAM-1/LFA-1 interaction have been implicated in the glomerular accumulation of monocytes/macrophages (Mo/Mφ) and crescent formation in anti-glomerular basement membrane (GBM) glomerulonephritis of WKY rats. In the present study, the participation of CD8^+lym and inflammatory cytokines in the expression of ICAM-1 and the accumulation of Mo/Mφ in the glomeruli was examined. ICAM-1 expression and Mo/Mφ accumulation were markedly enhanced in the glomeruli after anti-GBM antibody injection. By depleting the CD8^+lym in the circulation, the increased expression of ICAM-1 and glomerular accumulation of Mo/Mφ were suppressed, indicating a crucial role of CD8^+lym in the enhancement of ICAM-1 expression and the Mo/Mφ accumulation. Expression of mRNA for IL-1β, TNFα and IFNγ, known to enhance ICAM-1 expression, was induced in the glomeruli at a mRNA level in a similar profile to that of ICAM-1 expression. The CD8^+lym depletion also suppressed the induction of mRNA expression for these cytokines except for IL-1β. These results indicate CD8^+lym up-regulate the expression of ICAM-1 probably through induction of TNFα and IFNγ and play a role in the accumulate Mo/Mφ.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 110, 号 6, p. 210-212, 発行日 1996-06
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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