@article{oai:niigata-u.repo.nii.ac.jp:00018068,
 author = {皆河, 崇志 and 相場, 豊隆 and 新井田, 広仁 and 藤井, 幸彦 and 田中, 隆一},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {The mechanism of neovascularization in brain was investigated in vitro. Cultured microvascular endothelial cells, astrocytes, pericytes and glioma cells from brain were used in this study. Proliferation of endothelial cells was stimulated by type 1 collagen and moderate hypoxia. Conditioned media from glioma cells failed to fascilitate the growth of endothelial cells. Differentiation of endothelial cells, demonstrated by the formation of capillatry-like structure was stimulated the existence of type 1 collagen. Glioma cells also stimulated the formation of capillary-like structures. Astrocytes migrated and attached to the capillary-like structures, and the formation of blood-brain barrier, proved by the induction of tight junction was observed 9 days after the attactment. Pericytes also migrated and attached to the capillary-like structures.},
 pages = {197--202},
 title = {1) 脳における血管新生のメカニズムに関する検討 : 培養細胞(内皮, 腫瘍, アストロサイト等)を利用したアプローチ(シンポジウム 血管細胞生物学の進歩, 第517回新潟医学会)},
 volume = {110},
 year = {1996}
}