@article{oai:niigata-u.repo.nii.ac.jp:00017967,
 author = {前島, 威人},
 issue = {8},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Aug},
 note = {The aim of this study was to elucidate what sort of gastric adenoma transforms into malignancy and where cancer develops in adenomatous tubule. The object was 111 gastric adenomas and 10 carcinoma arising in adenoma. p53 and Ki-67 immunostaing was performed for objective detection of small foci of microscopic carcinoma. Malignant transformation was found only in adenoma of high-grade cytological atypia and of 19mm or more in size. The rate was 8.3% (10/121) in total, 0% (0/71) in tumors less than 10mm, 8.7% (2/23) in 10≦x<20mm tumors, and 29.2% (8/27) in 20≦x tumors. Microscopic cancer was found in the proliferative zone (superficial layer) of adenomatous tubules by p53 immunostaing. The cancer tissue was of low-grade in cytological atypia, and cancer cells were Ki-67 positive. Then, cancer cells extended downwards along the adenomatous tubules. This is the first report which objectively verified these processes by p53 and Ki-67 immunostaing.},
 pages = {337--347},
 title = {胃腺腫の癌化率と癌の形態発生 : p53とKi-67免疫染色からみて},
 volume = {110},
 year = {1996}
}