@article{oai:niigata-u.repo.nii.ac.jp:00017833,
 author = {桶谷, 典弘},
 issue = {10},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Oct},
 note = {To evaluate the usefulness of bronchoalveolar lavage (BAL) test, the cellular components of BAL fluid (BALF) was studied in 97 patients with untreated sarcoidosis. Total cell counts and number and percentage of alveolar macrophages (AM) in 48 smokers were significantly increased than those in 49 nonsmokers. However, there was no significant difference in number, percentage and CD4^+/CD8^+ of lymphocytes between two groups. Concerning the relationship between BALF lymphocyte and chest X-ray findings, the number and percentage of lymphocytes in BALF of stage I and stage II were significantly higher than those of stage 0. The lymphocyte numbers in BALF were correlated with the serum levels of angiotensin converting enzyme. The number and percentage of lymphocytes in BALF in patients with epithelioid cell granuloma were higher than those in the patients without granuloma. In addition, there was a positive correlation between the mean channel of HLA-DR antigen expression on AM and number, percentage or CD^4+/CD^8+ of lymphocytes in BALF, suggesting that the interaction of AM and lymphocytes may contribute to the occurrence of sarcoidosis. Moreover, the number and percentage of lymphocytes in BALF were significantly lower in patients with normal chest X-ray findings confirmed within one year after the initial diagnosis than those of patients with abnormal chest X-ray findings. These results indicate that the analysis of BALF is surely useful for evaluating the activity and prognosis of pulmonary sarcoidosis.},
 pages = {438--449},
 title = {サルコイドーシスにおける気管支肺胞洗浄検査の意義について},
 volume = {110},
 year = {1996}
}