@article{oai:niigata-u.repo.nii.ac.jp:00017745,
 author = {山本, 和男 and 渡辺, 弘 and 宮村, 治男 and 林, 純一 and 江口, 昭治 and 佐藤, 一範 and 渡辺, 逸平},
 issue = {12},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Dec},
 note = {It had not been efficient to manage pulmonary hypertensive crisis（PH crisis）until nitric oxide（NO）, an endothelium-derived relaxing factor（EDRF）was applied clinically as pulmonary vasodilators. We experienced two cases of PH crisis after surgery for congenital heart diseases that were refractory to traditional medical therapy. Patient 1：A 7-month-old girl with ventricular septal defect（VSD）and severe pulmonary hypertension（pulmonary artery pressure/systemic pressure；Pp/Ps＝0.97 and pulmonary vascular resistance/systemic vascular resistance；Rp/Rs＝0.80）underwent VSD closure. In the intensive care unit, NO inhalation was applied for the treatment of PH crisis. Twenty ppm of inhaled NO alleviated pulmonary hypertension without causing systemic hypotension and improved oxygenation. On the second postoperative day, the girl was safely weaned from inhaled NO therapy. Patient 2：A 1-year-old girl with complete endocardial cushion defect（ECD）and pulmonary hypertension（Pp/Ps＝0.83, Rp/Rs＝0.20）underwent intracardiac repair. She could not be weaned from cardiopulmonary bypass（CPB）because of oversystemic pulmonary hypertension. Following NO inhalation right ventricular pressure/aortic pressure ratio decreased from 1.2 to 0.8, which enabled her to be weaned from CPB. Inhaled NO was terminated after 10 days of low level usage. In conclusion, inhaling low levels of NO provides a useful and safe means to treat PH crisis following surgery for congenital heart disease, and it may help increasing oxygenation by improving ventilation/perfusion ratio.},
 pages = {577--583},
 title = {開心術後の肺高血圧症に対するNO吸入療法},
 volume = {110},
 year = {1996}
}