@article{oai:niigata-u.repo.nii.ac.jp:00017420,
 author = {堀川, 洋 and 那波, 宏之},
 issue = {5},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {May},
 note = {To investigate the relationship between striatal dopaminergic function and behavior, we simultaneously examined the intrastriatal kinetics of the dopamine antagonist sulpiride and cataleptic behavior using in vivo voltammetry. First, we confirmed that sulpiride, a D2 antagonist, could be measured in vivo with this technique. Sulpiride current intensity was measured when the potential was increased from 750 to 850 mV. Then sulpiride was administered into the striatum of freely moving rats. Sulpiride levels increased and remained high for more than 3h. Cataleptic behavior also continued for 3h. The duration of cataleptic behavior correlated well with that increase in sulpiride. Sulpiride kinetics was compared with that of dopamine and 1-methyl-1, 4-phenylpyridi-nium（MPP＋）. Dopamine and MPP＋ were administered intrastriatally and were taken up into dopaminergic neurons within 1h after the end of injection. These findings suggest that sulpiride is not taken up or metabolized.},
 pages = {319--327},
 title = {線条体内スルピリド濃度変化とカタレプシーとの関係 : In vivo voltammetryを用いた研究},
 volume = {111},
 year = {1997}
}