@article{oai:niigata-u.repo.nii.ac.jp:00017283,
 author = {宇野, 勝次},
 issue = {7},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jul},
 note = {The methods to detect the allergenic drugs, the pathogenic mechanism of drug allergy and the age-related change of drug allergy were studied. The results indicate the following. 1. Leucocyte migration inhibition test (LMIT) constitutes an effective means of detecting the allergenic drugs. 2. Lymphokines play a major role in the pathogenesis of drug allergy. 3. Both leucocyte migration activating factor (LMAF) and leucocyte migration inhibitory factor (LMIF) are involved in drug allergy. 3. LMAF is induced during the early period of allergenic drug-sensitization, whereas LMIF is produced during the late period of the sensitization. 4. Drug-sensitized lymphocytes produce IL-2 in response to stimulation by drug-antigens and IL-2 increases the production of LMAF. 5. IFNγ may be partly involved in drug allergy. 6. The proportion of positive LMIT has two peaks in each age category and this change may come from the age-related alternation in the peripheral blood lymphocyte counts. 7. Aged persons have a high incidence in drug allergy and this causation may come from the age-related change in drug-treated patients. 8. Antibiotic drugs, central nervous drugs and cardiovascular drugs form more than 85% of all allergenic drugs. 9. Aged persons have a high incidence of allergenic cardiovascular drugs and this causation may come from the age-related change in administered drugs. 10. Aged persons have longer latent periods and this causation may come from the low activity of lymphocytes.},
 pages = {415--424},
 title = {1) アレルギー性副作用(シンポジウム 薬剤の副作用, 第518回新潟医学会)},
 volume = {111},
 year = {1997}
}