{"created":"2021-03-01T06:21:43.505055+00:00","id":17080,"links":{},"metadata":{"_buckets":{"deposit":"521c60ac-0fa1-4dae-a48a-dde84533bd21"},"_deposit":{"id":"17080","owners":[],"pid":{"revision_id":0,"type":"depid","value":"17080"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00017080","sets":["453:456","471:537:538:1116"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The Effect of Anti-αβ T Cell Receptor Antibody in Rat Heart Transplantation and Lung Transplantation"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"567","bibliographicPageStart":"556","bibliographicVolumeNumber":"111","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It was previously demonstrated that preoperative administration of anti-αβ T cell receptor monoclonal antibody (R73) induced specific unresponsiveness to heart and kidney allografts in a fully MHC incompatible rat strain. In this study, the part of this mechanism was examined by molecular technique. Heterotopic heart and orthtopic left lung transplantation were performed. Experimental groups were divided as follows：Group 1, control group which were injected control antibody once a day for two consecutive days, beginning two days before transplantation. Group 2, preoperative treatment group which were injected R73 for two days as group 1. Group 3, postoperative treatment group which were injected R73 once a day for seven consecutive days, beginning on the day of transplantation. Heart grafts survived more than 200 days only in group 2. On the other hand, lung grafts were rejected with five days delay compared with control group. Phenotypic and functional analyses of T cells obtained from rats treated with R73 suggest that TCR molecules and function of T cells are transiently down-regulated at the time of transplantation. In RNase protection assay, expression of cytokine mRNA on grafts was suppressed only in group 2. These data suggest that exposure to alloantigen during T cell modulation suppress cytokine production which initiate and enhance graft rejection. In normal lung but not heart, cytokine and adhesion molecule were detected in mRNA level. This may be one of the reason of early graft rejection in lung transplantation.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"108079","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Watanabe, Takehiro"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡辺, 健寛"}],"nameIdentifiers":[{"nameIdentifier":"108078","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-08"}],"displaytype":"detail","filename":"111(9)_556-567.pdf","filesize":[{"value":"3.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"111(9)_556-567.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/17080/files/111(9)_556-567.pdf"},"version_id":"29cb600c-0987-47a4-ba11-d141def3b794"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"lung transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"heart transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"cytokine","subitem_subject_scheme":"Other"},{"subitem_subject":"αβ T cell receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"monoclonal antibody","subitem_subject_scheme":"Other"},{"subitem_subject":"肺移植","subitem_subject_scheme":"Other"},{"subitem_subject":"心移植","subitem_subject_scheme":"Other"},{"subitem_subject":"サイトカイン","subitem_subject_scheme":"Other"},{"subitem_subject":"αβ T細胞受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"モノクローナル抗体","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラット心移植および肺移植モデルにおける抗 αβ T細胞受容体抗体投与による生着延長効果に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラット心移植および肺移植モデルにおける抗 αβ T細胞受容体抗体投与による生着延長効果に関する研究"},{"subitem_title":"ラット心移植および肺移植モデルにおける抗 αβ T細胞受容体抗体投与による生着延長効果に関する研究","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1116"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-01-06"},"publish_date":"2017-01-06","publish_status":"0","recid":"17080","relation_version_is_last":true,"title":["ラット心移植および肺移植モデルにおける抗 αβ T細胞受容体抗体投与による生着延長効果に関する研究"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:48:31.401999+00:00"}