{"created":"2021-03-01T06:21:43.376330+00:00","id":17078,"links":{},"metadata":{"_buckets":{"deposit":"824178d2-54f6-46fd-8789-101c6385c294"},"_deposit":{"id":"17078","owners":[],"pid":{"revision_id":0,"type":"depid","value":"17078"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00017078","sets":["453:456","471:537:538:1116"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Pathogenesis of Lupus Nephritis : Role of Histones, DNA, Nucleosome, Anti-Nuclear Antibodies"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"546","bibliographicPageStart":"541","bibliographicVolumeNumber":"111","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A possibility involving cationic nuclear autoantigens is presented in detail. Histone was employed as a model antigen, representative of this group. Histones were shown to have high affinity for the rat GBM；they could also acted as planted antigen and induce IC formation；furthermore they were able to mediate the binding of highly anionic DNA. The demonstration of histones in glomerular deposits in both lupus mice and patients with SLE is important evidence, linking such molecules with the kidney lesions. Nucleosome-like structures as well as nucleosome-anti-DNA immune complexes were shown to have the affinity for the GBM. We discussed the importance of the nucleosome in the induction of lupus nephritis.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"108075","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Morioka, Tetsuo"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森岡, 哲夫"}],"nameIdentifiers":[{"nameIdentifier":"108074","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-08"}],"displaytype":"detail","filename":"111(9)_541-546.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"111(9)_541-546.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/17078/files/111(9)_541-546.pdf"},"version_id":"5f5230c4-aebd-4216-9feb-6deffb0bb33b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"lupus nephritis","subitem_subject_scheme":"Other"},{"subitem_subject":"nucleosome","subitem_subject_scheme":"Other"},{"subitem_subject":"charge","subitem_subject_scheme":"Other"},{"subitem_subject":"histones","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-DNA antibody","subitem_subject_scheme":"Other"},{"subitem_subject":"ループス腎炎","subitem_subject_scheme":"Other"},{"subitem_subject":"ヌクレオソーム","subitem_subject_scheme":"Other"},{"subitem_subject":"荷電","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒストン","subitem_subject_scheme":"Other"},{"subitem_subject":"抗 DNA 抗体","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ループス腎炎発症機序 : ヒストン・DNA・ヌクレオソーム・抗核抗体の役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ループス腎炎発症機序 : ヒストン・DNA・ヌクレオソーム・抗核抗体の役割"},{"subitem_title":"ループス腎炎発症機序 : ヒストン・DNA・ヌクレオソーム・抗核抗体の役割","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1116"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-01-06"},"publish_date":"2017-01-06","publish_status":"0","recid":"17078","relation_version_is_last":true,"title":["ループス腎炎発症機序 : ヒストン・DNA・ヌクレオソーム・抗核抗体の役割"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:48:31.802560+00:00"}