@article{oai:niigata-u.repo.nii.ac.jp:00017078,
 author = {森岡, 哲夫},
 issue = {9},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Sep},
 note = {A possibility involving cationic nuclear autoantigens is presented in detail. Histone was employed as a model antigen, representative of this group. Histones were shown to have high affinity for the rat GBM；they could also acted as planted antigen and induce IC formation；furthermore they were able to mediate the binding of highly anionic DNA. The demonstration of histones in glomerular deposits in both lupus mice and patients with SLE is important evidence, linking such molecules with the kidney lesions. Nucleosome-like structures as well as nucleosome-anti-DNA immune complexes were shown to have the affinity for the GBM. We discussed the importance of the nucleosome in the induction of lupus nephritis.},
 pages = {541--546},
 title = {ループス腎炎発症機序 : ヒストン・DNA・ヌクレオソーム・抗核抗体の役割},
 volume = {111},
 year = {1997}
}