{"_buckets": {"deposit": "8e363174-85c1-4699-a9ba-9f8b7689eb24"}, "_deposit": {"id": "16952", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "16952"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00016952"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Effects of Temperature and pH on Changes in Intracelluar Ca Ion Concentration of Rat Hippocampal Slices during Oxygen-Glucose Deprivation"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1997-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "712", "bibliographicPageStart": "705", "bibliographicVolumeNumber": "111", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Low temperature is commonly known to protect neurons against ischemia, and neuroprotective effect of mild acidosis has also been suggested in our recent reports. In this study, the effects of temperature and pH on ischemic cell damage were studied in terms of intracellular Ca^\u003c2+\u003e, as an indicator of ischemic cell damage, using rat hippocampal slice preparations. Intracellular Ca^\u003c2+\u003e concentration was measured by fluorometry using fura-2. Slices were exposed to ischemia by perfusion with glucose-free artificial CSF (ACSF) bubbled with 95% N_2-5% CO_2. Intracelluar Ca^\u003c2+\u003e showed a characteristic rapid increase at 334\u00b183 sec (n=24) following the start of ischemia at normal temperature (37\u2103). The latency of the characteristic rapid increase in intracellular Ca^\u003c2+\u003e was prolonged to 535\u00b149 sec (n=9) at low temperature (33\u2103), while it was shortened to 189\u00b139 sec (n=12) at high temperature (42\u2103). The latency of the rapid intracellular Ca2+ increase was shortened at each temperature in alkalized ACSF (pH 7.8). The characteristic rapid increase in intracellar Ca^\u003c2+\u003e was not observed at each temperature in acidified ACSF (pH 6.8). The results indicate that both temperature and pH affect the time to the rapid increase in intracellular Ca^\u003c2+\u003e in ischemic tissue, and suggest the neuroprotective effect of hypothermia as well as mild acidosis and also hypothermia plus mild acidosis.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "107357", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Ebine, Yoshiko"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u6d77\u8001\u6839, \u7f8e\u5b50"}], "nameIdentifiers": [{"nameIdentifier": "107356", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "111(11)_705-712.pdf", "filesize": [{"value": "1.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1800000.0, "url": {"label": "111(11)_705-712.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/16952/files/111(11)_705-712.pdf"}, "version_id": "dd20dd4c-ee03-4e03-9506-0f396aac5e54"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "pH", "subitem_subject_scheme": "Other"}, {"subitem_subject": "temperature", "subitem_subject_scheme": "Other"}, {"subitem_subject": "intracellular Ca ion concentration", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ischemia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "oxygen-glucose deprivation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u6e29\u5ea6", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u7d30\u80de\u5185 Ca \u30a4\u30aa\u30f3\u6fc3\u5ea6", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u865a\u8840", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u4f4e\u9178\u7d20\u30fb\u7121\u30b0\u30eb\u30b3\u30fc\u30b9", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u4f4e\u9178\u7d20\u30fb\u7121\u30b0\u30eb\u30b3\u30fc\u30b9\u8ca0\u8377\u4e2d\u306e\u30e9\u30c3\u30c8\u6d77\u99ac\u5207\u7247\u7d30\u80de\u5185Ca\u30a4\u30aa\u30f3\u6fc3\u5ea6\u4e0a\u6607\u306b\u5bfe\u3059\u308b\u6e29\u5ea6\u3068pH\u306e\u5f71\u97ff", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u4f4e\u9178\u7d20\u30fb\u7121\u30b0\u30eb\u30b3\u30fc\u30b9\u8ca0\u8377\u4e2d\u306e\u30e9\u30c3\u30c8\u6d77\u99ac\u5207\u7247\u7d30\u80de\u5185Ca\u30a4\u30aa\u30f3\u6fc3\u5ea6\u4e0a\u6607\u306b\u5bfe\u3059\u308b\u6e29\u5ea6\u3068pH\u306e\u5f71\u97ff"}, {"subitem_title": "\u4f4e\u9178\u7d20\u30fb\u7121\u30b0\u30eb\u30b3\u30fc\u30b9\u8ca0\u8377\u4e2d\u306e\u30e9\u30c3\u30c8\u6d77\u99ac\u5207\u7247\u7d30\u80de\u5185Ca\u30a4\u30aa\u30f3\u6fc3\u5ea6\u4e0a\u6607\u306b\u5bfe\u3059\u308b\u6e29\u5ea6\u3068pH\u306e\u5f71\u97ff", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1114"], "permalink_uri": "http://hdl.handle.net/10191/45515", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2017-01-13"}, "publish_date": "2017-01-13", "publish_status": "0", "recid": "16952", "relation": {}, "relation_version_is_last": true, "title": ["\u4f4e\u9178\u7d20\u30fb\u7121\u30b0\u30eb\u30b3\u30fc\u30b9\u8ca0\u8377\u4e2d\u306e\u30e9\u30c3\u30c8\u6d77\u99ac\u5207\u7247\u7d30\u80de\u5185Ca\u30a4\u30aa\u30f3\u6fc3\u5ea6\u4e0a\u6607\u306b\u5bfe\u3059\u308b\u6e29\u5ea6\u3068pH\u306e\u5f71\u97ff"], "weko_shared_id": null}