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低酸素・無グルコース負荷中のラット海馬切片細胞内Caイオン濃度上昇に対する温度とpHの影響
http://hdl.handle.net/10191/45515
http://hdl.handle.net/10191/455153ba95c07-8afa-40b6-a285-b2ad6b6edf74
名前 / ファイル | ライセンス | アクション |
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111(11)_705-712.pdf (1.8 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-01-13 | |||||
タイトル | ||||||
タイトル | 低酸素・無グルコース負荷中のラット海馬切片細胞内Caイオン濃度上昇に対する温度とpHの影響 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 低酸素・無グルコース負荷中のラット海馬切片細胞内Caイオン濃度上昇に対する温度とpHの影響 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pH | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | temperature | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | intracellular Ca ion concentration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ischemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | oxygen-glucose deprivation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 温度 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 細胞内 Ca イオン濃度 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 虚血 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 低酸素・無グルコース | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Effects of Temperature and pH on Changes in Intracelluar Ca Ion Concentration of Rat Hippocampal Slices during Oxygen-Glucose Deprivation | |||||
著者 |
海老根, 美子
× 海老根, 美子 |
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著者別名 | ||||||
識別子 | 107357 | |||||
識別子Scheme | WEKO | |||||
姓名 | Ebine, Yoshiko | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Low temperature is commonly known to protect neurons against ischemia, and neuroprotective effect of mild acidosis has also been suggested in our recent reports. In this study, the effects of temperature and pH on ischemic cell damage were studied in terms of intracellular Ca^<2+>, as an indicator of ischemic cell damage, using rat hippocampal slice preparations. Intracellular Ca^<2+> concentration was measured by fluorometry using fura-2. Slices were exposed to ischemia by perfusion with glucose-free artificial CSF (ACSF) bubbled with 95% N_2-5% CO_2. Intracelluar Ca^<2+> showed a characteristic rapid increase at 334±83 sec (n=24) following the start of ischemia at normal temperature (37℃). The latency of the characteristic rapid increase in intracellular Ca^<2+> was prolonged to 535±49 sec (n=9) at low temperature (33℃), while it was shortened to 189±39 sec (n=12) at high temperature (42℃). The latency of the rapid intracellular Ca2+ increase was shortened at each temperature in alkalized ACSF (pH 7.8). The characteristic rapid increase in intracellar Ca^<2+> was not observed at each temperature in acidified ACSF (pH 6.8). The results indicate that both temperature and pH affect the time to the rapid increase in intracellular Ca^<2+> in ischemic tissue, and suggest the neuroprotective effect of hypothermia as well as mild acidosis and also hypothermia plus mild acidosis. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 111, 号 11, p. 705-712, 発行日 1997-11 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |