{"created":"2021-03-01T06:21:28.138591+00:00","id":16843,"links":{},"metadata":{"_buckets":{"deposit":"e163d2e8-62ae-4fb9-a029-f873c69a2769"},"_deposit":{"id":"16843","owners":[],"pid":{"revision_id":0,"type":"depid","value":"16843"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00016843","sets":["453:456","471:537:538:1111"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Comparison of α1- and α2- Adrenoceptor Blocking Effects of Ifenprodil in the Isolated Rabbit Aorta and Ear Vein"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"88","bibliographicPageStart":"81","bibliographicVolumeNumber":"112","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ifenprodil is used as a remedy for late effects of cerebral infarction or hemorrhage. Although a-blocking effect of ifenprodil was already reported, its selectivity for subtypes ofα-adrenoceptors has not been properly studied yet. In the present study, using isolated rabbit aorta and ear vein, we investigated the blocking effects of ifenprodil on α_1- and α_2- adrenoceptors in comparison with those of prazosin, a selective α_1-blocker, and yohimbine, a selective α_2-blocker. In our experimental setup, prazosin was 1846 times more potent in blocking aradrenoceptor than α_2-adrenoceptor, and yohimbine was 33 times more potent in blocking α_2-adrenoceptor than α_1-adrenoceptor. The pA2 values for ifenprodil on α_1-and α_2-adrenoceptor were 7.55 ± 0.06 and 6.73 ± 0.18, respectively. Thus, ifenprodil was only 6.6 times more potent in blocking α_1-adrenoceptor than α_2-adrenoceptor. These results suggest that ifenprodil is a non-selective adrenoceptor blocking agent.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"106792","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nakazawa, Mikio"}]},{"nameIdentifiers":[{"nameIdentifier":"106793","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Watanabe, Yasuo"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"仲澤, 幹雄"}],"nameIdentifiers":[{"nameIdentifier":"106790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺, 資夫"}],"nameIdentifiers":[{"nameIdentifier":"106791","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"112(2)_81-88.pdf","filesize":[{"value":"983.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"112(2)_81-88.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/16843/files/112(2)_81-88.pdf"},"version_id":"b49a19b2-bca5-4d01-94a0-67739a352875"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ifenprodil","subitem_subject_scheme":"Other"},{"subitem_subject":"prazosin","subitem_subject_scheme":"Other"},{"subitem_subject":"yohimbine","subitem_subject_scheme":"Other"},{"subitem_subject":"α-blocking effects","subitem_subject_scheme":"Other"},{"subitem_subject":"rabbit arota","subitem_subject_scheme":"Other"},{"subitem_subject":"rabbit ear vein","subitem_subject_scheme":"Other"},{"subitem_subject":"イフェンプロジール","subitem_subject_scheme":"Other"},{"subitem_subject":"プラゾシン","subitem_subject_scheme":"Other"},{"subitem_subject":"ヨヒンビン","subitem_subject_scheme":"Other"},{"subitem_subject":"α受容体遮断作用","subitem_subject_scheme":"Other"},{"subitem_subject":"ウサギ大動脈","subitem_subject_scheme":"Other"},{"subitem_subject":"ウサギ耳介静脈","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Ifenprodilのα1およびα2受容体遮断作用についての研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ifenprodilのα1およびα2受容体遮断作用についての研究"},{"subitem_title":"Ifenprodilのα1およびα2受容体遮断作用についての研究","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1111"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-01-20"},"publish_date":"2017-01-20","publish_status":"0","recid":"16843","relation_version_is_last":true,"title":["Ifenprodilのα1およびα2受容体遮断作用についての研究"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:48:21.400947+00:00"}