@article{oai:niigata-u.repo.nii.ac.jp:00016843,
 author = {仲澤, 幹雄 and 渡辺, 資夫},
 issue = {2},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Feb},
 note = {Ifenprodil is used as a remedy for late effects of cerebral infarction or hemorrhage. Although a-blocking effect of ifenprodil was already reported, its selectivity for subtypes ofα-adrenoceptors has not been properly studied yet. In the present study, using isolated rabbit aorta and ear vein, we investigated the blocking effects of ifenprodil on α_1- and α_2- adrenoceptors in comparison with those of prazosin, a selective α_1-blocker, and yohimbine, a selective α_2-blocker. In our experimental setup, prazosin was 1846 times more potent in blocking aradrenoceptor than α_2-adrenoceptor, and yohimbine was 33 times more potent in blocking α_2-adrenoceptor than α_1-adrenoceptor. The pA2 values for ifenprodil on α_1-and α_2-adrenoceptor were 7.55 ± 0.06 and 6.73 ± 0.18, respectively. Thus, ifenprodil was only 6.6 times more potent in blocking α_1-adrenoceptor than α_2-adrenoceptor. These results suggest that ifenprodil is a non-selective adrenoceptor blocking agent.},
 pages = {81--88},
 title = {Ifenprodilのα1およびα2受容体遮断作用についての研究},
 volume = {112},
 year = {1998}
}