@article{oai:niigata-u.repo.nii.ac.jp:00016842,
 author = {浅野, 堅策},
 issue = {2},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Feb},
 note = {Chromosome analysis of patients with recurrent abortion who were positive for anticardiolipin antibody was performed in order to elucidate whether the frequency of chromosome abnormalities of the patient couples is significantly different from that in general population or not. Between January, 1987 and June, 1995, 487 patients with recurrent abortion were registered at the Outpatient Clinic for Infertility of Niigata University School Hospital. Anticardiolipin antibody was positive in 79 out of the 487 women (positive rate：16.2 %) and negative in the remaining 408 (negative rate：83.8 %). Chromosomes of the patients and their husbands were examined with their informed consent. Two out of the 158 individuals of 79 positive cases (1.27 %) revealed chromosome abnormalities (a triple X of the patient in one case and a reciprocal translocation of the husband in the other). Twenty-one of the 816 individuals of 408 patient couples (2.57 %) negative for anticardiolipin antibody (the patients in 12 cases and their husbands in 9) had chromosome abnormalities. These frequency of chromosome abnormalities were compared with that in general population previously reported by Jacobs P.A. et al. analyzing 11,680 newborn infants. No significant difference was observed between the rate of chromosome abnormalities in patient couples with recurrent abortion positive for anticardiolipin antibody and that in general population. However, the frequency of chromosome abnormalities in patient couples with recurrent abortion negative for anticardiolipin antibody was significantly higher than that in general population (p < 0.0001). The statistically similar frequency of chromosome abnormalities of couples in recurrent aborters positive for anticardiolipin antibody as that in general population strongly suggests that the anticardiolipin antibody is implicated in the genesis of recurrent abortions in the patients.},
 pages = {76--80},
 title = {抗リン脂質抗体陽性不育症々例における患者夫婦染色体異常に関する研究},
 volume = {112},
 year = {1998}
}