@article{oai:niigata-u.repo.nii.ac.jp:00016823,
 author = {竹内, 菊博},
 issue = {3},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Mar},
 note = {ACE (angiotensin I couverting enzyme) gene was examined by polymerase chain reaction (PCR) in 36 subjects who had a past history of Kawasaki disease (16 without coronary aneurysm 20 with coronary aneurysm). A polymorphism in the ACE gene was characterized by three genotypes：two D alleles (genotype DD), two I alleles (genotype II), and heterozygotes allele (genotype DI), Genotype II was found in 65 % of the subjects with aneurysm and 12.5 % of those without aneurysm (p < 0.01, Odds ratio 13.0, 95 % confidence intervals). Although the mechanism of aneurysm formation in Kawasaki disease is unknown, the present study showed that the frequency of II genotype is significantly higher in subjects with Kawasaki disease and coronary aneurysm than in those without aneurysm. These findings suggest that II genotype may contribute to vascular dilatation, contrary to the predisposition of DD genotype to vascular stenosis.},
 pages = {144--150},
 title = {川崎病におけるアンギオテンシンI変換酵素遺伝子多型と冠動脈病変合併に関する検討},
 volume = {112},
 year = {1998}
}