{"created":"2021-03-01T06:21:20.293977+00:00","id":16721,"links":{},"metadata":{"_buckets":{"deposit":"0a714d86-3f1a-4bf5-a698-30241a17974f"},"_deposit":{"id":"16721","owners":[],"pid":{"revision_id":0,"type":"depid","value":"16721"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00016721","sets":["453:456","471:537:538:1108"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Pathogenesis of the Experimental Models of Glomerulonephritis Induced by Monoclonal Antibodies"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"225","bibliographicPageStart":"219","bibliographicVolumeNumber":"112","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Two nephritogenic monoclonal antibodies (mAbs) were produced in BALB/c mice immunized with rat glomeruli. The first mAb (mAb 5-1-6) identifies a 51-kDa protein (p51) on rat glomerular epithelial cell foot processes, mainly slit membrane and causes severe complement- and leukocyte-independent proteinuria when injected into rats. p51 first became detectable on the basal and lateral sides of the developing glomerular epithelium at the S-shaped body stage and became concentrated in the slit pore with the interdigitation of foot processes. p51 and ZO-1, a known component of tight junction, were closely localized at the slit membrane in the mature glomerulus but arrived at their final position from opposite directions. After mAb 5-1-6 injection, there was a progressive decline in stainnable ZO-1 and p51 in the glomerular epithelium of heavily proteinuric rats. We concluded that mAb 5-1-6 alters the molecular composition of the slit membrane and thereby affects the glomerular permeability barrier. The second mAb (mAb 1-22-3)binds the limited mesangial cell surface facing endothelial cells and causes the morphological changes similar to those induced by anti-thymocyte serum (ATS) and severe proteinuria in rats by a single i.v. injection. The mesangial lesion induced by ATS is reversible and not always accompanied with severe proteinuria. The model induced by the single injection of mAb 1-22-3 is also reversible. We succeeded in inducing irreversible mesangial changes with persistent proteinuria by two consecutive injections 2 weeks apart of a mAb 1-22-3. This model should be the best model to investigate the mechanism of chronic progression of human mesangial proliferative glomerulonephritis.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"106111","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kawachi, Hiroshi"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河内, 裕"}],"nameIdentifiers":[{"nameIdentifier":"106110","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"112(5)_219-225.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"112(5)_219-225.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/16721/files/112(5)_219-225.pdf"},"version_id":"2c66d0ee-b572-4e10-90f1-8c346c286fec"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"monoclonal antibody","subitem_subject_scheme":"Other"},{"subitem_subject":"proteinuria","subitem_subject_scheme":"Other"},{"subitem_subject":"slit membrane","subitem_subject_scheme":"Other"},{"subitem_subject":"glomerular epithelial cell","subitem_subject_scheme":"Other"},{"subitem_subject":"mesangial cell","subitem_subject_scheme":"Other"},{"subitem_subject":"単クローン抗体","subitem_subject_scheme":"Other"},{"subitem_subject":"蛋白尿","subitem_subject_scheme":"Other"},{"subitem_subject":"スリット膜","subitem_subject_scheme":"Other"},{"subitem_subject":"糸球体上皮細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"メサンギウム細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"単クローン抗体により惹起されるモデルを用いた糸球体腎炎の発症, 進行機序の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"単クローン抗体により惹起されるモデルを用いた糸球体腎炎の発症, 進行機序の解析"},{"subitem_title":"単クローン抗体により惹起されるモデルを用いた糸球体腎炎の発症, 進行機序の解析","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1108"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-01-30"},"publish_date":"2017-01-30","publish_status":"0","recid":"16721","relation_version_is_last":true,"title":["単クローン抗体により惹起されるモデルを用いた糸球体腎炎の発症, 進行機序の解析"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:48:13.472197+00:00"}