{"_buckets": {"deposit": "0a714d86-3f1a-4bf5-a698-30241a17974f"}, "_deposit": {"id": "16721", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "16721"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00016721", "sets": ["456", "1108"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Pathogenesis of the Experimental Models of Glomerulonephritis Induced by Monoclonal Antibodies"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1998-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "225", "bibliographicPageStart": "219", "bibliographicVolumeNumber": "112", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Two nephritogenic monoclonal antibodies (mAbs) were produced in BALB/c mice immunized with rat glomeruli. The first mAb (mAb 5-1-6) identifies a 51-kDa protein (p51) on rat glomerular epithelial cell foot processes, mainly slit membrane and causes severe complement- and leukocyte-independent proteinuria when injected into rats. p51 first became detectable on the basal and lateral sides of the developing glomerular epithelium at the S-shaped body stage and became concentrated in the slit pore with the interdigitation of foot processes. p51 and ZO-1, a known component of tight junction, were closely localized at the slit membrane in the mature glomerulus but arrived at their final position from opposite directions. After mAb 5-1-6 injection, there was a progressive decline in stainnable ZO-1 and p51 in the glomerular epithelium of heavily proteinuric rats. We concluded that mAb 5-1-6 alters the molecular composition of the slit membrane and thereby affects the glomerular permeability barrier. The second mAb (mAb 1-22-3)binds the limited mesangial cell surface facing endothelial cells and causes the morphological changes similar to those induced by anti-thymocyte serum (ATS) and severe proteinuria in rats by a single i.v. injection. The mesangial lesion induced by ATS is reversible and not always accompanied with severe proteinuria. The model induced by the single injection of mAb 1-22-3 is also reversible. We succeeded in inducing irreversible mesangial changes with persistent proteinuria by two consecutive injections 2 weeks apart of a mAb 1-22-3. This model should be the best model to investigate the mechanism of chronic progression of human mesangial proliferative glomerulonephritis.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "106111", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kawachi, Hiroshi"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "河内, 裕"}], "nameIdentifiers": [{"nameIdentifier": "106110", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "112(5)_219-225.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "112(5)_219-225.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/16721/files/112(5)_219-225.pdf"}, "version_id": "2c66d0ee-b572-4e10-90f1-8c346c286fec"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "monoclonal antibody", "subitem_subject_scheme": "Other"}, {"subitem_subject": "proteinuria", "subitem_subject_scheme": "Other"}, {"subitem_subject": "slit membrane", "subitem_subject_scheme": "Other"}, {"subitem_subject": "glomerular epithelial cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mesangial cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "単クローン抗体", "subitem_subject_scheme": "Other"}, {"subitem_subject": "蛋白尿", "subitem_subject_scheme": "Other"}, {"subitem_subject": "スリット膜", "subitem_subject_scheme": "Other"}, {"subitem_subject": "糸球体上皮細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "メサンギウム細胞", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "単クローン抗体により惹起されるモデルを用いた糸球体腎炎の発症, 進行機序の解析", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "単クローン抗体により惹起されるモデルを用いた糸球体腎炎の発症, 進行機序の解析"}, {"subitem_title": "単クローン抗体により惹起されるモデルを用いた糸球体腎炎の発症, 進行機序の解析", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1108"], "permalink_uri": "http://hdl.handle.net/10191/45831", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-01-30"}, "publish_date": "2017-01-30", "publish_status": "0", "recid": "16721", "relation": {}, "relation_version_is_last": true, "title": ["単クローン抗体により惹起されるモデルを用いた糸球体腎炎の発症, 進行機序の解析"], "weko_shared_id": null}