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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第112巻第5号

単クローン抗体により惹起されるモデルを用いた糸球体腎炎の発症, 進行機序の解析

http://hdl.handle.net/10191/45831
http://hdl.handle.net/10191/45831
5dc13b19-1d02-4911-b980-303d197e30d8
名前 / ファイル ライセンス アクション
112(5)_219-225.pdf 112(5)_219-225.pdf (1.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-01-30
タイトル
タイトル 単クローン抗体により惹起されるモデルを用いた糸球体腎炎の発症, 進行機序の解析
タイトル
言語 en
タイトル 単クローン抗体により惹起されるモデルを用いた糸球体腎炎の発症, 進行機序の解析
言語
言語 jpn
キーワード
主題Scheme Other
主題 monoclonal antibody
キーワード
主題Scheme Other
主題 proteinuria
キーワード
主題Scheme Other
主題 slit membrane
キーワード
主題Scheme Other
主題 glomerular epithelial cell
キーワード
主題Scheme Other
主題 mesangial cell
キーワード
主題Scheme Other
主題 単クローン抗体
キーワード
主題Scheme Other
主題 蛋白尿
キーワード
主題Scheme Other
主題 スリット膜
キーワード
主題Scheme Other
主題 糸球体上皮細胞
キーワード
主題Scheme Other
主題 メサンギウム細胞
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Pathogenesis of the Experimental Models of Glomerulonephritis Induced by Monoclonal Antibodies
著者 河内, 裕

× 河内, 裕

WEKO 106110

河内, 裕

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著者別名
識別子 106111
識別子Scheme WEKO
姓名 Kawachi, Hiroshi
抄録
内容記述タイプ Abstract
内容記述 Two nephritogenic monoclonal antibodies (mAbs) were produced in BALB/c mice immunized with rat glomeruli. The first mAb (mAb 5-1-6) identifies a 51-kDa protein (p51) on rat glomerular epithelial cell foot processes, mainly slit membrane and causes severe complement- and leukocyte-independent proteinuria when injected into rats. p51 first became detectable on the basal and lateral sides of the developing glomerular epithelium at the S-shaped body stage and became concentrated in the slit pore with the interdigitation of foot processes. p51 and ZO-1, a known component of tight junction, were closely localized at the slit membrane in the mature glomerulus but arrived at their final position from opposite directions. After mAb 5-1-6 injection, there was a progressive decline in stainnable ZO-1 and p51 in the glomerular epithelium of heavily proteinuric rats. We concluded that mAb 5-1-6 alters the molecular composition of the slit membrane and thereby affects the glomerular permeability barrier. The second mAb (mAb 1-22-3)binds the limited mesangial cell surface facing endothelial cells and causes the morphological changes similar to those induced by anti-thymocyte serum (ATS) and severe proteinuria in rats by a single i.v. injection. The mesangial lesion induced by ATS is reversible and not always accompanied with severe proteinuria. The model induced by the single injection of mAb 1-22-3 is also reversible. We succeeded in inducing irreversible mesangial changes with persistent proteinuria by two consecutive injections 2 weeks apart of a mAb 1-22-3. This model should be the best model to investigate the mechanism of chronic progression of human mesangial proliferative glomerulonephritis.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 112, 号 5, p. 219-225, 発行日 1998-05
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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