@article{oai:niigata-u.repo.nii.ac.jp:00016369,
 author = {藤井, 雅寛},
 issue = {10},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Oct},
 note = {Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia. Tax, the viral protein, is thought to be crucial in the development of the disease, since it is transforming in vitro and induces tumors in transgenic animals. We examined the effect of Tax activity on the growth of an interleukin (IL)-2-dependent T-cell line, CTLL-2. A stable expression of Tax in CTLL-2 converted cell growth from being IL-2-dependent to IL-2-independent. Tax stimulated the transcription through NF-kB and cAMP responsive element like sequence (CRE) in HTLV-1 promoter. Tax mutants segregating these two pathways suggested that the NF-kB pathway was essential for IL-2-independent growth of CTLL-2, while that of CRE was unnecessary. The level of Tax expresssion in five IL-2-dependent HTLV-1-transformed T-cell lines positively correlated with their survival length in the absence of, IL-2. Three IL-2-independent cell lines expressed more Tax protein than most of IL-2-dependent ones. However, one IL-2-dependent cell lines expressed Tax equivalently to that of IL-2-independent ones, and it was still IL-2-dependent. These results suggested that Tax in enough amount is required but not sufficient for long-term IL-2-independent proliferation of virus-infected T-cell lines.},
 pages = {585--588},
 title = {ヒトT細胞白血病ウイルス1型Tax蛋白によるT細胞のIL-2非依存性細胞増殖誘導機構},
 volume = {112},
 year = {1998}
}