@article{oai:niigata-u.repo.nii.ac.jp:00016297,
 author = {内藤, 眞 and 高塚, 尚和 and 江部, 祐輔 and 伊藤, 重雄 and 梅津, 哉},
 issue = {11},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Nov},
 note = {Mice homozygous for the osteopetrosis (op) mutation are characterized by defective differentiation of osteoclasts, monocytes, and tissue macrophages due to a lack of functional macrophage colony-stimulating factor (M-CSF/CSF-1) activity. In young (4-6 week-old) op/op mice, the bone marrow cavities were filled with spongious bone. In aged (50-72-week-old) op/op mice, the bone marrow cavities were markedly reconstructed and marrow hematopoiesis was expanded. Numbers of osteoclasts and bone marrow macrophages in aged op/op mice were increased but most of the osteoclasts were mononuclear cells and showed poorly developed ruffled borders. In contrast to the marked increase in numbers of osteoclasts and macrophages in the bone marrow, the number of Kupffer cells in the liver did not increase in aged op/op mice. M-CSF administration to aged op/op mice induced numerical increases in Kupffer cells and the development of ruffled border in osteoclasts. These findings indicate that M-CSF-independent mechanisms for bone marrow hematopoiesis and macrophage and osteoclast development function in aged op/op mice.},
 pages = {675--679},
 title = {3)マクロファージコロニー刺激因子欠損マウス(op)の加齢による骨髄造血の変化（シンポジウム サイトカインの基礎と臨床応用, 第537回新潟医学会）},
 volume = {112},
 year = {1998}
}