@article{oai:niigata-u.repo.nii.ac.jp:00016295, author = {渡部, 久実}, issue = {11}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Nov}, note = {Many functions of cells of the immune system are mediated through the production of cytokines. CD4+ helper T cells differentiate functionally into one of two subsets, Th1 or Th2. Th1 cells generate IL-2 and IFNγ and support the cellular immune responses. On the other hand, Th2 cells generate IL-4, IL-5 and IL-10 and support the humoral immune responses. A unique population of T cells that carry intermediate levels of TCR exist in the liver and other immune organs. These T cells express IL-2Rβ-chain and receptors of the NK cell lineage. Many investigators call them intTCR cells or NKT cells. Recently, it was demonstrated that NKT cells produce IL-4 and IFN-γ and regulate the differentiation of CD4^+ helper T cells into Th1 or Th2 cells. These findings indicate that NKT cells play an important role of immune regulation by cytokines.}, pages = {667--670}, title = {1)T細胞をめぐるサイトカイン : 最近の話題(シンポジウム サイトカインの基礎と臨床応用, 第537回新潟医学会)}, volume = {112}, year = {1998} }