{"_buckets": {"deposit": "812b615d-af37-4b39-a873-63d612cd49dd"}, "_deposit": {"id": "16219", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "16219"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00016219", "sets": ["456", "1100"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Development of Fatty Acid Derivatives Labeled with Short-lived Positron Emitters and Its Application for PET Studies"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1999-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "13", "bibliographicPageStart": "1", "bibliographicVolumeNumber": "113", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "For the development of myocardial imaging tracers in PET (positron emission computed tomography) studies, new labeling methods and new radiopharmaceuticals of [^\u003c11\u003eC]/[^\u003c18\u003eF] labeled fatty acid derivatives were investigated. In [^\u003c11\u003eC] labeling of fatty acids, a new chemical approach to the preparation of [1-^\u003c11\u003eC] fatty acids from [^\u003c11\u003eC] HCN was developed. This method has some advantages, such as no requirement of absolutely anhydrous solvent, easy [^\u003c11\u003eC] labeling using an extremely small amount of substrate, and good reproducibility. From these advantages, it has been shown that this new approach is one of efficient synthetic methods of [1-^\u003c11\u003eC] labeled fatty acids for use in routine PET studies. While, in [^\u003c18\u003eF] labeling of fatty acids, 5-methyl-17-[^\u003c18\u003eF] fluoroheptadecanoic acid (5-MFHA) was proposed as a new myocardial imaging tracer for PET studies. From accumulation studies and metabolic studies of the heart muscle, 5-MFHA showed some properties, such as the relatively high initial uptake, the longer retention of myocardial accumulation and the quite similar metabolic pattern in the myocardium to that of straight-chain-fatty acids. These properties demonstrate that 5-MFHA is one of the structually modified fluorofatty acids and may be one of available myocardial imaging tracers. According to PET studies, this expectation is well supported.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "103444", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Takahashi, Toshihiro"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "高橋, 俊博"}], "nameIdentifiers": [{"nameIdentifier": "103443", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "113(1)_1-13.pdf", "filesize": [{"value": "1.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1900000.0, "url": {"label": "113(1)_1-13.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/16219/files/113(1)_1-13.pdf"}, "version_id": "d1b82a8c-d49f-4b38-9504-2f268f5b8ba2"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "[^\u003c11\u003eC]/[^\u003c18\u003eF]labeled fatty acid derivatives", "subitem_subject_scheme": "Other"}, {"subitem_subject": "PET", "subitem_subject_scheme": "Other"}, {"subitem_subject": "[^\u003c11\u003eC]HCN", "subitem_subject_scheme": "Other"}, {"subitem_subject": "5-methyl-17-[^\u003c18\u003eF]fluoroheptadecanoic acid", "subitem_subject_scheme": "Other"}, {"subitem_subject": "myocardial imaging tracers", "subitem_subject_scheme": "Other"}, {"subitem_subject": "[^\u003c11\u003eC]/[^\u003c18\u003eF]標識脂肪酸誘導体", "subitem_subject_scheme": "Other"}, {"subitem_subject": "陽電子断層撮像法", "subitem_subject_scheme": "Other"}, {"subitem_subject": "[^\u003c11\u003eC]標識シアン化水素", "subitem_subject_scheme": "Other"}, {"subitem_subject": "5-メチル-17-[^\u003c18\u003eF]フルオロヘプタデカン酸", "subitem_subject_scheme": "Other"}, {"subitem_subject": "心筋イメージング剤", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "陽電子放出核種で標識された脂肪酸関連診断薬の開発とその医学利用", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "陽電子放出核種で標識された脂肪酸関連診断薬の開発とその医学利用"}, {"subitem_title": "陽電子放出核種で標識された脂肪酸関連診断薬の開発とその医学利用", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1100"], "permalink_uri": "http://hdl.handle.net/10191/46471", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-02-16"}, "publish_date": "2017-02-16", "publish_status": "0", "recid": "16219", "relation": {}, "relation_version_is_last": true, "title": ["陽電子放出核種で標識された脂肪酸関連診断薬の開発とその医学利用"], "weko_shared_id": null}