@article{oai:niigata-u.repo.nii.ac.jp:00016188, author = {樋口, 宗史}, issue = {2}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Feb}, note = {It is an unsolved question how the neuron-specific genes are . regulated in the mature neurons. The neuronal regulation of neuropeptide Y (NPY) gene which is a cotransmitter of sympathetic neurons and expressed abundantly in the central nervous system. The regulation of this gene resembles that of tyrosine hydroxylase gene.Both the membrane depolarization induced by neural activity and neurotrophic factors such as NGF induced the transcriptiional activation of NPY and enkephalin genes. These mechanisms are due to both Ca/almodulin and MAPK (mitogen-activated protein kinase) dependent processes, respectively. These findings indicated that the transcriptional activations of neural genes are due to the novel transactivational mechanisms. The novel transcriptional factors will be reported.}, pages = {77--82}, title = {交感神経・中枢神経の神経ペプチドNPYの遺伝子発現と機能 : 神経分化, 記憶に関わる遺伝子制御}, volume = {113}, year = {1999} }