@article{oai:niigata-u.repo.nii.ac.jp:00001616, author = {Sato, Tsutomu and Hoshino, Tsutomu and Abe, Takamasa}, issue = {23}, journal = {Chemical communications, Chemical communications}, month = {Dec}, note = {Site-directed mutagenesis experiments with W169F, W169H and W489F for the squalene-hopene cyclase, and the formation of 10 possessing the five-membered D-ring and a tetrahydrofuran moiety as the enzyme product of the analogue 8 with a hydroxy group, strongly suggest that a ring expansion reaction from the five- to the six-membered ring is responsible for the D-ring formation of hopene.}, pages = {2617--2618}, title = {On the cyclization mechanism of squalene : a ring expansion process of the five-membered D-ring intermediate}, volume = {1998}, year = {1998} }