{"created":"2021-03-01T06:05:16.624930+00:00","id":1605,"links":{},"metadata":{"_buckets":{"deposit":"1ff9a1b4-218f-4a6a-9af2-730a1be6a1a4"},"_deposit":{"id":"1605","owners":[],"pid":{"revision_id":0,"type":"depid","value":"1605"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00001605","sets":["453:454","471:472:473"]},"author_link":["4556","4557","4558","4559","4560","4561","4562","4563","4564","4565","4566"],"control_number":"1605","item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"288","bibliographicPageStart":"278","bibliographicVolumeNumber":"68","bibliographic_titles":[{"bibliographic_title":"Cardiovascular Reseach"},{"bibliographic_title":"Cardiovascular Reseach","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: In a heart with myocarditis, there are cardiomyocytes, inflammatory cells and non-inflammatory interstitial cells. Immunologic molecules are thought to influence not only inflammatory cells but also cardiac function and remodeling. Whatever their origin, the cells they target and crosstalk by them remain unclear. Here, we examined native gene expression of immunologic molecules in normal and rat experimental autoimmune myocarditis (EAM) days 18 and 90 after immunization, using real time RT-PCR in cardiomyocytes, CD11b+ cells, αβT cells and non-cardiomyocytic non-inflammatory (NCNI) cells. Methods and results: Cells were isolated by collagenase perfusion on a Langendorff apparatus and purified by passing through a stainless-steel sieve followed by magnetic bead column separation using appropriate monoclonal antibodies. Most immunologic molecules were expressed in inflammatory cells. However, some of them were expressed in NCNI cells or cardiomyocytes. Interestingly, most of Interleukine (IL)-10, monocyte chemoattractant protein (MCP)-1 or tumor necrosis factor (TNF)-α receptor was found in NCNI cells and most offractalkine was found in NCNI cells and cardiomyocytes. Moreover, TNF-α significantly upregulated fractalkine and MCP-1 mRNA in cultivated cells from EAM hearts. Conclusion: In rat experimental myocarditis heart, inflammatory cells express many immunologic molecules. Some of them are thought to influence NCNI cells or cardiomyocytes directly via receptors on these cell types. It is further suggested that fractalkine, IL-10 and MCP-1 expressed in NCNI cells or cardiomyocytes regulate inflammatory cells.","subitem_description_type":"Abstract"}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"4566","nameIdentifierScheme":"WEKO"}],"names":[{"name":"塙, 晴雄"}]}]},"item_5_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"16018993","subitem_relation_type_select":"PMID"}}]},"item_5_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/j.cardiores.2005.06.006","subitem_relation_type_select":"DOI"}}]},"item_5_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"European Society of Cardiology.Published by Elsevier B.V."}]},"item_5_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA0059904X","subitem_source_identifier_type":"NCID"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00086363","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshida, Tsuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"4556","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hanawa, Haruo"}],"nameIdentifiers":[{"nameIdentifier":"4557","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toba, Ken"}],"nameIdentifiers":[{"nameIdentifier":"4558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"4559","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Ritsuo"}],"nameIdentifiers":[{"nameIdentifier":"4560","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Kaori"}],"nameIdentifiers":[{"nameIdentifier":"4561","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Abe, Satoru"}],"nameIdentifiers":[{"nameIdentifier":"4562","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Kiminori"}],"nameIdentifiers":[{"nameIdentifier":"4563","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kodama, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"4564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aizawa, Yoshifusa"}],"nameIdentifiers":[{"nameIdentifier":"4565","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-29"}],"displaytype":"detail","filename":"22_0002.pdf","filesize":[{"value":"904.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22_0002.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/1605/files/22_0002.pdf"},"version_id":"6cfa03e7-e51b-468f-af73-9d24ed3ca2c8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Myocarditis","subitem_subject_scheme":"Other"},{"subitem_subject":"Dilated cardiomyopathy","subitem_subject_scheme":"Other"},{"subitem_subject":"Autoimmunity","subitem_subject_scheme":"Other"},{"subitem_subject":"Chemokines","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytokines","subitem_subject_scheme":"Other"},{"subitem_subject":"Quantitative RT-PCR","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Expression of Immunological molecues expression of cadomyocytes, inflammatory and interstitial cells in rat autoimmune myocarditis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of Immunological molecues expression of cadomyocytes, inflammatory and interstitial cells in rat autoimmune myocarditis","subitem_title_language":"en"}]},"item_type_id":"5","owner":"1","path":["454","473"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-04-23"},"publish_date":"2007-04-23","publish_status":"0","recid":"1605","relation_version_is_last":true,"title":["Expression of Immunological molecues expression of cadomyocytes, inflammatory and interstitial cells in rat autoimmune myocarditis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-15T03:34:19.978314+00:00"}