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Expression of coxsackievirus and adenovirus receptor(CAR) in neointima of the rat carotid artery
http://hdl.handle.net/10191/1185
http://hdl.handle.net/10191/11853eed3d7c-8c9c-4ade-ae48-8d3c06aa53ff
名前 / ファイル | ライセンス | アクション |
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24_0010.pdf (1.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-04-23 | |||||
タイトル | ||||||
タイトル | Expression of coxsackievirus and adenovirus receptor(CAR) in neointima of the rat carotid artery | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Expression of coxsackievirus and adenovirus receptor(CAR) in neointima of the rat carotid artery | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Coxsackievirus and Adenovirus receptor (CAR) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | intimal hyperplasia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vascular smooth muscle cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | balloon injury | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Nasuno, Akimitsu
× Nasuno, Akimitsu× Toba, Ken× Ozawa, Takuya× Hanawa, Haruo× Osman, Yasser× Hotta, Yuko× Yoshida, Kaori× Saigawa, Takashi× Kato, Kiminori× Kuwano, Ryozo× Watanabe, Kenichi× Aizawa, Yoshifusa |
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著者別名 | ||||||
識別子 | 4555 | |||||
識別子Scheme | WEKO | |||||
姓名 | 鳥羽, 健 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Our previous study revealed that the coxsackievirus and adenovirus receptor (CAR) is a homophilic cell adhesion molecule and may function as a sensor of cell-cell interactions in the brain and damaged heart. In this study, we investigated if CAR expression is involved in the formation of neointimal hyperplasia using a balloon injury model of rat carotid artery. Cultured vascular smooth muscle cells (SMCs) from rat aorta were also studied. CAR antigen was constitutively detected in the endothelial cells (ECs) but not in SMCs before injury. On day 5 after balloon injury, CAR was expressed strongly in the first layer of medial SMCs. Neointimal hyperplasia was observed on day 7, and strong expressions of CAR concomitantly with proliferating cell nuclear antigen (PCNA) were obvious in the neointimal SMCs, while CAR in medial SMCs disappeared. The expression of CAR mRNA reached a peak on day 7 and declined gradually to the basal levels. When the ECs regenerated on day 14, CAR antigen was observed in the ECs but disappeared in the neointima. CAR together with PCNA was expressed abundantly in the proliferating SMCs in vitro, and diminished in cells grown to a con fluent state. The abundant expression of CAR in the neointima may facilitate an adenoviral gene therapy. | |||||
書誌情報 |
Cardiovascular Pathology en : Cardiovascular Pathology 巻 13, 号 2, p. 79-84, 発行日 2004-02 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10548807 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10993310 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/S1054-8807(03)00137-6 | |||||
権利 | ||||||
権利情報 | Elsevier Inc. | |||||
著者版フラグ | ||||||
値 | author |