@article{oai:niigata-u.repo.nii.ac.jp:00015995,
 author = {青柳, 豊 and 須田, 剛士 and 川合, 弘一 and 見田, 有作 and 柳, 雅彦 and 和栗, 暢生 and 横田, 隆司 and 鈴木, 康史 and 朝倉, 均},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {In order to unveil a role of the genomic instability（loss of heterozygosity, LOH and replication error, RER）, telomerase activity and fucosylated species of alphafetoprotein（fucosylation index, FI）with its enzymatic background in hepatocarcinogenesis, they were simultaneously determined in hepatocellular carcinoma（HCC）, surrounding non－tumorous liver（SL）, normal liver（NL）and patients sera. LOH was significantly frequent in HCC compared with SL or NL. In contrast, RER was detected at random loci and not significantly frequent in HCC. Both of LOH and RER were tended to appear preferentially in SL than in NL. The mean relative telomerase activity in patients suffering from early recurrences after surgery was significantly higher than that in patients without intrahepatic recurrence. The analysis of multiple co－variates in the prognostic factors by the Cox’s proportional hazards model showed that FI was one of the independent prognostic factors. When the tentative discriminating line of FI was set at 18％, the mean survival rate in the group, whose FI was higher than 18％, was significantly lower than another group, whose FI is equal to or less than 18％, by the generalized Wilcoxon and the log rank tests.　These　results　suggest　that　measuring　these　indicators　serves　as　new　prognostic　and　predictive　factors　and　may　improve　prognostic\nestimates　and　appraisal　of　therapeutic　outcome　for　patients　with　HCC．},
 pages = {297--303},
 title = {肝細胞癌におけるゲノム不安定性とテロメラーゼ活性ならびに糖転移酵素活性の基礎的, 臨床的研究},
 volume = {113},
 year = {1999}
}