@article{oai:niigata-u.repo.nii.ac.jp:00015723, author = {染矢, 俊幸}, issue = {11-12}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Dec}, note = {The development of pharmacokinetics and pharmacogenetics in a last decade has been clarifying the background of remarkable interindividual variability in the metabolism of psychotropic drugs and its clinical significance. This article reviewed the followings: Interindividual variability in plasma concentration of psychotropic drugs, relationship between plasma concentration of psychotropic drugs and its clinical effect, genetic polymorphism of the enzyme which is involved in psychotropic drug metabolism, pharmacokinetic drug-drug interaction, effect of aging on pharmacokinetics, etc.. On the basis of further development of this area in psychiatry, it is desired that more rational psychiatric pharmacotherapy will be established.}, pages = {507--515}, title = {向精神薬代謝の個体差と薬物相互作用:薬理遺伝学の進歩とその応用について}, volume = {113}, year = {1999} }