@article{oai:niigata-u.repo.nii.ac.jp:00015602, author = {張, 高明}, issue = {2}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Feb}, note = {Chemotherapy has been playing a major role in the treatment of various cancers especially in advanced stage. Chemotherapy is the only way to get complete disappearance of tumor cells (total cell kill) in hematological malignancies, such as acute leukemia and lymphoma. Several therapeutic strategies including highdose chemotherapy with stem cell transplantation has been performed and resulted in the cure of the diseases, even in case of advanced, refractory phase. These results demonstrated that complete remission or response is essential for the ultimate cure of the disease, since there is no cure in case of partial response or stable disease. Unfortunately, present chemotherapeutic approaches are not effective enough to get CR in various solid tumors. The main reason for this tragety is that the chemotherapeutic agents used in current treatment protocol do not possess enough anti-tumor activity to eradicate vast majority of the tumor cells. Palliative chemotherapy should also be considered in case of advanced cancer with minimal chemo-sensitivity. Because of this, development of new cytotoxic anticancer agents is essential. Other than this, different therapeutic approaches, such as clinical application of apoptosis inducing agents, angiogenesis inhibitor, and adhesion molecule blocker, which may inhibit distant metastases.}, pages = {35--38}, title = {1) 化学療法(シンポジウム 進行癌の治療, 第548回新潟医学会)}, volume = {114}, year = {2000} }