{"created":"2021-03-01T06:05:13.502870+00:00","id":1554,"links":{},"metadata":{"_buckets":{"deposit":"4eff7ecb-714c-4f55-be38-edf260e6cae5"},"_deposit":{"id":"1554","owners":[],"pid":{"revision_id":0,"type":"depid","value":"1554"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00001554","sets":["453:454","482:483:484"]},"author_link":["4260","4261","4262","4263","4264","4265","4266","4267","4268","4269","4270","4271"],"control_number":"1554","item_1627363077551":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"994","bibliographicPageStart":"987","bibliographicVolumeNumber":"344","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Erythropoietin (EPO) has been known to have cytoprotective effects on several types of tissues, presumably through modulation of apoptosis and inflammation. The effect of EPO on myocardial inflammation, however, has not yet been clarified. We investigated the cardioprotective effects of EPO in rats with experimental autoimmune myocarditis (EAM). Seven-week-old Lewis rats immunized with cardiac myosin were treated either with EPO or vehicle and were examined on day22. EPO attenuated the functional and histological severity of EAM along with suppression of mRNAs of tumor necrosis factor (TNF)-a and interleukin (IL)-6 in the hearts as well as a reduction of apoptotic cardiomyocytes. The EPO receptor (EPO-R) was upregulated in the myocardium of EAM compared with that of healthy rats. These results may suggest that EPO ameliorated the progression of EAM by modulating myocardial inflammation and apoptosis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"4271","nameIdentifierScheme":"WEKO"}],"names":[{"name":"鳥羽, 健","nameLang":"ja"}]}]},"item_5_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_5_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://doi.org/10.1016/j.bbrc.2006.03.230","subitem_relation_type_select":"DOI"}}]},"item_5_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Elsevier Inc."}]},"item_5_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00564395","subitem_source_identifier_type":"NCID"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mitsuma, Wataru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kodama, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fuse, Koichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4263","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okamura, Kazuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4264","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minagawa, Shiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Kiminori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hanawa, Haruo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toba, Ken","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakazawa, Mikio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aizawa, Yoshifusa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4270","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-29"}],"displaytype":"detail","filename":"24_0007.pdf","filesize":[{"value":"4.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"24_0007.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/1554/files/24_0007.pdf"},"version_id":"813d26e1-b2ab-4faf-940d-d8c2572cfa5f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Erythropoietin","subitem_subject_scheme":"Other"},{"subitem_subject":"Experimental autoimmune myocarditis","subitem_subject_scheme":"Other"},{"subitem_subject":"Erythropoietin receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"Apoptosis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cardioprotective effects of recombinant human erythropoietin in rats with Experimental autoimmune myocarditis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cardioprotective effects of recombinant human erythropoietin in rats with Experimental autoimmune myocarditis","subitem_title_language":"en"}]},"item_type_id":"5","owner":"1","path":["454","484"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-04-23"},"publish_date":"2007-04-23","publish_status":"0","recid":"1554","relation_version_is_last":true,"title":["Cardioprotective effects of recombinant human erythropoietin in rats with Experimental autoimmune myocarditis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-15T04:35:46.329902+00:00"}