@article{oai:niigata-u.repo.nii.ac.jp:00015494,
 author = {高橋, 栄明},
 issue = {4},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Apr},
 note = {Bone is a dynamic tissue, which remodels continuously throughout life, besides enchondral ossification in growth. In remodeling bone resorption precedes formative activity, being shown as the Haversian Systems, concentric lamellar structure in cross section of cortical bone, firstly reported in Chicago, 1964. Remodeling also occurs in cancellous bone as trabecular packets, lamellar structure. In bone histomorphometry mineral appositional rate may be measured using bone marking agent, such as tetracycline antibiotics, and undemineralized bone section. Initially cross section of 11th rib was used, but cancellous bone of ilium was established as a standard site of bone remodeling assessment. Since 1965 in Niigata bone histomorphometry has shown bone biodynamics in human and animal bone, i. e. , dogs and rats. It was demonstrated microelectrical current enhanced remodeling of cortical bone of dogs and large difference of metabolism between high and low turnover of osteoporosis. Intermittent administration of human parathyroid hormone （1-34） increased cancellous bone volume. In clinical study incidence of femoral neck fracture was surveyed in 1985, ’87, ’89 and ’94. And it demonstrated lower fracture rate in Japanese than in Caucasians of Europe and the United States. Operative treatment of osteoporotic spine was performed and showed need of not only medical treatment, but surgical approach for neurological complication of crushed fracture of vertebral body and continuous back pain Japanese osteoporosis assessment questionnaire was made disease-targeted and cross-cultural questions.},
 pages = {137--146},
 title = {最終講義 : 「骨は生きている」 : 私の骨代謝研究と国際交流},
 volume = {114},
 year = {2000}
}