@article{oai:niigata-u.repo.nii.ac.jp:00015405, author = {中川, 理 and 丸山, 誠太郎 and 金子, 晋 and 長沼, 景子 and 浮須, 潤子 and 相澤, 義房}, issue = {6}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Jun}, note = {It has drawn attention for some time that diabetes mellitus, hypertension, hyperlipemia and obesity are found in the same patients, and accumulation of such risk factors is liable to cause arteriosclerotic cardiac diseases. In recent years, involvement of insulin resistance and hyperinsulinemia has been reported in many cases as a common factor in such glucose metabolism disorder, essential hypertension, lipid metabolism disorder and obesity. In the action mechanism of insulin resistance and the resultant hyperinsulinemia to compensate insulin resistance inducing various pathological states, involvement of biological activities of insulin other than glucose metabolism are conceived. Insulin shows vasodilation, acceleration of sodium reabsorption in the kidneys, cell growth and potentiation of sympathetic nerves, and insulin resistance is considered to cause dysfunction leading to hypertension. In this study, we report insulin resistance and hypertension based on the results in our department and discussion of literature.}, pages = {223--227}, title = {5)高血圧症に合併する病態 : インスリン抵抗性(シンポジウム 高血圧治療の進歩, 第556回新潟医学会)}, volume = {114}, year = {2000} }