@article{oai:niigata-u.repo.nii.ac.jp:00015404, author = {塙, 晴雄}, issue = {6}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Jun}, note = {Hypertension is known to cause cardiovascular damage, and can lead to heart, kidney or brain failure. The final goal for the treatment of hypertension is to prevent. such organ failure. On the other hand, recent advances in the fields of molecular and vascular biology are unraveling the mysteries of cardiovascular remodeling that leads to arteriosclerosis and cardiac hypertrophy. These conditions are formed by physiologically active substances (such as tissue renin-angiotensin, endothelin, natriuretic peptide, NO, etc.) which are secreted as autocrine or paracrine. Once the remodeling mechanism is fully understood, the clinician will be able to select the most effective drugs to treat hypertension.}, pages = {221--223}, title = {4)高血圧症における臓器障害のメカニズム : 心血管系のリモデリング(シンポジウム 高血圧治療の進歩, 第556回新潟医学会)}, volume = {114}, year = {2000} }