@article{oai:niigata-u.repo.nii.ac.jp:00015402, author = {山崎, 元義}, issue = {6}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Jun}, note = {Hypertension is the most important risk factor of cerebrovascular disease. Its management is urgent problem in our community, especially in this era of Brain Attack. It has been established that antihypertensive drug treatment reduces the rate of stroke, not only fatal, but also non-fatal. Recent megatrials show that calcium channel blockers and ACE inhibitors are also effective other than betablockers and diuretics for primary prevention of stroke. But secondary prevention of stroke of these drugs are not established. Further studies are needed to clarify the effect and mechanism of antihypertension treatment for the prevention of stroke. The presence of J-curve phenomenon, different prognosis between dipper and non-dipper are matters of controversy. Recently, MRI revealed the presence of asymptomatic silent cerebral lesions. These are considered subclinical stroke and closely associated with hypertension. But its mechanism and treatment are not known. Stroke Data Bank is indispensable for stroke prevention research in our community.}, pages = {216--218}, title = {2)地域社会における高血圧症の位置づけ : 脳血管障害との関連(シンポジウム 高血圧治療の進歩, 第556回新潟医学会)}, volume = {114}, year = {2000} }