@article{oai:niigata-u.repo.nii.ac.jp:00014959,
 author = {倉林, 工},
 issue = {4},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Apr},
 note = {The etiology of postmenopausal osteoporosis has not completely been solved. Recent studies showed hypoestrogenic state caused the activation of cytokines (IL-1, IL-6, TNF-_α, GM-CSF etc. ) from monocyte, stromal cells and osteoblast in bone marrow, and activated bone resorption and suppressed bone formation. Hormone replacement therapy (HRT) is the first choice of the treatment for postmenopausal osteoporosis. HRT is effective for not only osteoporosis but also climacteric disturbance and hyperlipidemia. HRT causes the increase of bone mineral density within 2 years, and mainteins it after 2 years. Vitamin D receptor gene polymorphism (Taq) is useful to detect the effect of HRT for osteoporosis. It is important for us to detect the high risk women for osteoporosis. Ovarian dysfunction, castration and GnRH agonist therapy etc. are risk factors for osteoporosis. Pregnancy and lactation may not be risk factors. There are two factors, i.e. genetic factor and environmental factor, to cause osteoporosis. The evaluation of genetic factor and the improvement of life style are very important to prevent osteoporosis.},
 pages = {122--126},
 title = {3) 閉経後骨粗鬆症の病態・予防・治療（シンポジウム 骨粗鬆症の病態と治療, 第554回新潟医学会）},
 volume = {115},
 year = {2001}
}