{"created":"2021-03-01T06:19:25.929737+00:00","id":14958,"links":{},"metadata":{"_buckets":{"deposit":"cdd29f19-ae4c-4130-a48d-f0ed4f181621"},"_deposit":{"id":"14958","owners":[],"pid":{"revision_id":0,"type":"depid","value":"14958"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00014958","sets":["453:456","471:537:538:1076"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Uremia and Bone metabolic disorders"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"121","bibliographicPageStart":"118","bibliographicVolumeNumber":"115","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The increased skeletal resistance to PTH is a common abnormality underlying behind bone and calcium metabolic disorder associated with uremia, however, its presise pathophysiology remains unknown. The shortage of 1, 25-dihydroxyvitamin D is one of the factors to increase skeletal resistance, however, it is not the only patogenesis. Disturbed interaction between PTH and osteoblasts may account for, at least in part. We measured serum levels of osteoclastogenesis inhibitory factor/osteoprotegerin (OCIF/OPG), a natural circulating decoy ligand for osteoclast differentiation factor, in 46 predialysis patients and 21 dialysis patients to elucidate its involvement in the increased skeletal resistance to PTH found in uremia. Serum OCIF levels showed a positive correlation with creatinine levels. Twenty four hours-Ccr and the reciprocal number of serum OCIF level in predialysis patients also showed a clearer positive correlation. The OCIF molecules accumulated in uremic serum preserved the binding affinity to osteoclast differentiation factor. In conclusion, OCIF is a possible candidate for an uremic toxin to cause the increased skeletal resistance to PTH. The increased skeletal resistance to PTH should be the consequence of many factors associated with uremia.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"96346","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kazama, Junichiro James"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"風間, 順一郎"}],"nameIdentifiers":[{"nameIdentifier":"96345","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"115(4)_118-121.pdf","filesize":[{"value":"792.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"115(4)_118-121.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/14958/files/115(4)_118-121.pdf"},"version_id":"f0fdd9a3-3b55-474f-aebb-c7c7e5c7b79a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"uremia","subitem_subject_scheme":"Other"},{"subitem_subject":"skeletal resistance","subitem_subject_scheme":"Other"},{"subitem_subject":"osteoclast","subitem_subject_scheme":"Other"},{"subitem_subject":"OCIF/OPG","subitem_subject_scheme":"Other"},{"subitem_subject":"尿毒症","subitem_subject_scheme":"Other"},{"subitem_subject":"骨抵抗性","subitem_subject_scheme":"Other"},{"subitem_subject":"破骨細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"2) 骨の病態をめぐって : 腎疾患と骨疾患（シンポジウム 骨粗鬆症の病態と治療, 第554回新潟医学会）","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"2) 骨の病態をめぐって : 腎疾患と骨疾患（シンポジウム 骨粗鬆症の病態と治療, 第554回新潟医学会）"},{"subitem_title":"2) 骨の病態をめぐって : 腎疾患と骨疾患（シンポジウム 骨粗鬆症の病態と治療, 第554回新潟医学会）","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1076"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-07"},"publish_date":"2017-11-07","publish_status":"0","recid":"14958","relation_version_is_last":true,"title":["2) 骨の病態をめぐって : 腎疾患と骨疾患（シンポジウム 骨粗鬆症の病態と治療, 第554回新潟医学会）"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:46:49.615072+00:00"}