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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第115巻第4号

2) 骨の病態をめぐって : 腎疾患と骨疾患(シンポジウム 骨粗鬆症の病態と治療, 第554回新潟医学会)

http://hdl.handle.net/10191/48113
http://hdl.handle.net/10191/48113
538b49f0-2b7c-4c78-a857-702e49c5bdef
名前 / ファイル ライセンス アクション
115(4)_118-121.pdf 115(4)_118-121.pdf (792.7 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-11-07
タイトル
タイトル 2) 骨の病態をめぐって : 腎疾患と骨疾患(シンポジウム 骨粗鬆症の病態と治療, 第554回新潟医学会)
タイトル
言語 en
タイトル 2) 骨の病態をめぐって : 腎疾患と骨疾患(シンポジウム 骨粗鬆症の病態と治療, 第554回新潟医学会)
言語
言語 jpn
キーワード
主題Scheme Other
主題 uremia
キーワード
主題Scheme Other
主題 skeletal resistance
キーワード
主題Scheme Other
主題 osteoclast
キーワード
主題Scheme Other
主題 OCIF/OPG
キーワード
主題Scheme Other
主題 尿毒症
キーワード
主題Scheme Other
主題 骨抵抗性
キーワード
主題Scheme Other
主題 破骨細胞
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Uremia and Bone metabolic disorders
著者 風間, 順一郎

× 風間, 順一郎

WEKO 96345

風間, 順一郎

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著者別名
識別子 96346
識別子Scheme WEKO
姓名 Kazama, Junichiro James
抄録
内容記述タイプ Abstract
内容記述 The increased skeletal resistance to PTH is a common abnormality underlying behind bone and calcium metabolic disorder associated with uremia, however, its presise pathophysiology remains unknown. The shortage of 1, 25-dihydroxyvitamin D is one of the factors to increase skeletal resistance, however, it is not the only patogenesis. Disturbed interaction between PTH and osteoblasts may account for, at least in part. We measured serum levels of osteoclastogenesis inhibitory factor/osteoprotegerin (OCIF/OPG), a natural circulating decoy ligand for osteoclast differentiation factor, in 46 predialysis patients and 21 dialysis patients to elucidate its involvement in the increased skeletal resistance to PTH found in uremia. Serum OCIF levels showed a positive correlation with creatinine levels. Twenty four hours-Ccr and the reciprocal number of serum OCIF level in predialysis patients also showed a clearer positive correlation. The OCIF molecules accumulated in uremic serum preserved the binding affinity to osteoclast differentiation factor. In conclusion, OCIF is a possible candidate for an uremic toxin to cause the increased skeletal resistance to PTH. The increased skeletal resistance to PTH should be the consequence of many factors associated with uremia.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 115, 号 4, p. 118-121, 発行日 2001-04
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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